Cerebral Metabolism in Patients With Refractory Chronic Cluster Headache Treated by Occipital Nerve Stimulation
This trial is active, not recruiting.
|Condition||refractory chronic cluster headache|
|Sponsor||Centre Hospitalier Universitaire de Nice|
|Start date||March 2014|
|End date||July 2015|
|Trial size||20 participants|
|Trial identifier||NCT02081482, 13-AOI-05|
The occipital nerve stimulation (ONS) is used to treat patients with refractory primary chronic headache but its mechanism of action (MoA) remains unknown. Different hypothesis have been suggested in particular a specific action on cerebral generators involved in different types of primary headaches or a non specific action on pain modulatory network.
The aim of this study, using the chronic cluster headache as a model, is to determine the changes in cerebral metabolism induced by ONS to precise its MoA in the treatment of primary chronic headache.
|United States||No locations recruiting|
|Other Countries||No locations recruiting|
|Clermont Ferrand, France||CHU -Hôpital Gabriel Montpied||no longer recruiting|
|Marseille, France||Institut des Neurosciences||no longer recruiting|
|Nice, France||Département d'Evaluation et Traitement de la Douleur - Pôle Neurosciences Cliniques - Centre Hospitalo-Universitaire de Nice||no longer recruiting|
|Paris, France||Centre d'Urgence Céphalées||no longer recruiting|
|Intervention model||single group assignment|
|Primary purpose||health services research|
Adult subjects with refractory chronic cluster headache and ONS indication
Comparison of cerebral metabolism
time frame: Baseline (before ONS), 1 week after ONS , 3 month after ONS
Male or female participants at least 18 years old.
Inclusion Criteria: - age > 18 years - chronic cluster headache (according to the IHS) - refractory in who a treatment by ONS have been indicated - patient affiliated at social security, - informed consent signed Exclusion Criteria: - contraindication to MRI - contraindication to 18F-FDG PET - women without contraception/pregnant/breast-feeding - patient non-compliant - patient on legal guardianship
|Official title||Study of the Cerebral Metabolism in Patients With Refractory Chronic Cluster Headache Treated by Occipital Nerve Stimulation|
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