Clinical Evaluation, Biomarkers and Metabolomics of Sarcopenia in Frail Older Adults at Ambulatory Clinics
This trial is active, not recruiting.
|Sponsor||National Taiwan University Hospital|
|Collaborator||National Health Research Institutes, Taiwan|
|Start date||January 2011|
|End date||December 2018|
|Trial size||350 participants|
|Trial identifier||NCT02073370, 201010021R, EC0991002-E|
Sarcopenia related mobility dysfunction was a preventable presentation in transitional variation of frailty. However, the definition, associated risk factors, clinical course and outcome of sarcopenia in Taiwanese older adults are still under-clarified and need for further study.
The research subjects will be culled from outpatients aged over 65 at NTUH; 1000 Taiwanese subjects aged 20-40 equally divided in both genders will be recruited in order to establish the norm of Taiwanese's skeletal muscle index.
Domestic operation tool of sarcopenia for older adults
time frame: Baseline
Change from baseline in body composition during aging
time frame: up to 2 years
Male or female participants at least 65 years old.
Inclusion Criteria: - functional decline in recent one year - cognitive impairment - depressive symptom - mobility impairment - fall in recent one year - eating or feeding problems - weight loss - co-morbid conditions≧5 - tracking by different physician ≧3 in recent half year - poly-pharmacy≧8 in recent 3 months - hospitalization ≧1 in recent one year - emergency visits≧2 in recent one year - aged ≧ 80. Exclusion Criteria: - non-ambulatory (bed-ridden) patients - long-term residents at nursing homes - patients with a life expectancy shorter than six months - impairment in vision, hearing, or communicative ability, making convenience of clinical evaluation during the study period impossible.
|Official title||Clinical Evaluation, Biomarkers and Metabolomics of Sarcopenia in Frail Older Adults at Ambulatory Clinics|
|Principal investigator||Ching-Yu Chen, MD|
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