This trial is active, not recruiting.

Conditions sepsis, septic, septicemia
Sponsor King Abdullah International Medical Research Center
Start date February 2014
End date June 2014
Trial size 30 participants
Trial identifier NCT02069028, 0


This is a systematic review and Meta-Analysis of interventions for implementation of Surviving Sepsis Campaign guidelines and their impact on compliance and mortality reduction

United States No locations recruiting
Other Countries No locations recruiting

Primary Outcomes

Surviving Sepsis Campaign (SSC) Guidelines Compliance and Mortality
time frame: 2002 - 2014 (12 years)

Eligibility Criteria

Male or female participants of any age.

Inclusion Criteria: Any study or data 1. assessing any intervention method for implementing SSC guidelines in regards to compliance and mortality, 2. has a comparison group, 3. reported data on sepsis resuscitation bundle compliance and mortality Exclusion Criteria: Any study used other than SSC guidelines in sepsis management will be excluded.

Additional Information

Official title Effectiveness of Different Interventions for Implementing Surviving Sepsis Campaign (SSC) Guidelines on Compliance and Mortality: Systematic Review and Meta-analysis
Description The implementation of the sepsis resuscitation bundle recommended by the SSC guidelines has been shown to increase compliance and reduce mortality in several settings. Different implementation strategies have been utilized, including education, posters, reminders, audit and feedback, paper-based and electronic sepsis screening tools, clinical pathway and sepsis response teams. Different studies showed a considerable variation effect on compliance and mortality.It has been suggested that implantation strategies vary in there effect from low impact for human-based interventions such as education and training, rules and policies, reminders, checklists and double checks, however, reaching high effect for system based interventions like automation and computerization and forcing function. However, this has not been studied in relation to the implementation of SSC bundle. As such, many projects continue to invest on low-impact interventions with modest change in compliance and mortality. Multiple interventions were adopted by different centers worldwide to implement SSC guidelines. These interventions vary on their level of compliance and outcomes. The effectiveness of intervention if system oriented is more effective than human oriented. The hierarchy of effectiveness assigning forcing function intervention on the top of the pyramid and the training and education on the bottom. The investigators hypothesize that interventions system based interventions are more likely to be more effective in improving the compliance with sepsis resuscitation bundle and in improving mortality. The aim of this study is to assess the effectiveness of different interventions for implementation of Surviving Sepsis Campaign guidelines and their impact on compliance and mortality reduction.
Trial information was received from ClinicalTrials.gov and was last updated in February 2014.
Information provided to ClinicalTrials.gov by King Abdullah International Medical Research Center.