Overview

This trial is active, not recruiting.

Condition roux-en-y gastric bypass
Treatment roux-en-y gastric bypass
Sponsor Wageningen University
Collaborator Rijnstate Hospital
Start date July 2014
End date September 2017
Trial size 100 participants
Trial identifier NCT02068001, NL45837.081.13

Summary

It has been suggested that obese people are more sensitive to sensory and rewarding effects of food, aspects that mediate food preferences and intake. Individuals that underwent Roux-en-Y gastric bypass surgery frequently report changes in food preference. They indicate a decreased preference for highly rewarding energy dense foods. Changes in food preference might be related to alterations in central (brain) mechanisms, related to reward sensing. The smell and sight of food can be considered as anticipatory cues for the rewarding effects of food intake. The aim of this study is to determine the effect of gastric bypass surgery on (alterations in) food preferences. Secondly, this study aims at assessing the effect of gastric bypass surgery on the brain reward response when exposed to sight and smell of food stimuli with different sugar and fat contents.

United States No locations recruiting
Other Countries No locations recruiting

Study Design

Observational model cohort
Time perspective prospective
Arm
Food preference assessment in 100 patients at different timepoints, in a subset of 30 participants, also brain reward response to food cues will be assessed.
roux-en-y gastric bypass

Primary Outcomes

Measure
Development of food preferences after Roux-en-Y gastric bypass surgery
time frame: Participants will be followed for two years after they undergo surgery
Change in brain reward response to food cues
time frame: Before and 2 months after surgery

Secondary Outcomes

Measure
Plasma levels of endocannabinoids and satiety hormones
time frame: Before and 2 months after surgery

Eligibility Criteria

Male or female participants from 18 years up to 55 years old.

Inclusion Criteria: - Scheduled for Roux-en-Y Gastric Bypass Surgery at Rijnstate hospital Exclusion Criteria: - Lack of appetite - Having difficulties swallowing/eating - Being a vegetarian - Allergic to food product used as stimuli in the study

Additional Information

Official title Changes in Food Preference and Food Cue Responsivity After Bariatric Surgery
Principal investigator Suzanne EM de Bruijn, MSc
Trial information was received from ClinicalTrials.gov and was last updated in November 2016.
Information provided to ClinicalTrials.gov by Wageningen University.