Extending Ketamine's Effects in OCD With Exposure and Response Prevention (EX/RP)
This trial is active, not recruiting.
|Treatments||ketamine, exposure and response prevention|
|Sponsor||New York State Psychiatric Institute|
|Collaborator||National Institute of Mental Health (NIMH)|
|Start date||December 2013|
|End date||December 2015|
|Trial size||15 participants|
|Trial identifier||NCT02062658, #6811, K23MH092434|
This study investigates if a single dose of IV Ketamine can rapidly improve Obsessive-Compulsive Disorder (OCD) symptoms and whether these effect can be maintained with a condensed course of a type of Cognitive Behavioral Therapy called Exposure and Response Prevention (EX/RP). You will be compensated for your time and travel. Participants must be between the ages of 18-55.
|Endpoint classification||safety/efficacy study|
|Intervention model||single group assignment|
Improvement in severity of OCD symptoms as measured by the Yale-Brown Obsessive Compulsive Scale (YBOCS)
time frame: 4 weeks
Male or female participants from 18 years up to 55 years old.
Inclusion Criteria: - Age 18-55 - Physically healthy and not currently pregnant - Primary Diagnosis of OCD - Sufficient severity of symptoms - Currently off all psychotropic medication OR - Currently on adequate dose of medication for treatment of OCD, but have not achieved at least partial remission - Able to provide consent Exclusion Criteria: - Psychiatric conditions that make participation unsafe (schizophrenia [either self or first degree relative e.g. siblings, parents], history of violence, severe depression, eating disorder, substance dependence [including nicotine]) - Female patients who are either pregnant or nursing - Planning to commence EX/RP during the period of the study or those who have completed an adequate dose of EX/RP (defined as 8 or more sessions within 2 months) within 8 weeks prior to enrollment. period of the study - Allergy to ketamine - Participants for whom being off of medication is not clinically recommended - Medical conditions that make participation unsafe (e.g. high blood pressure, head injury) - Currently on medications that make participation unsafe
|Official title||Extending Ketamine's Effects in Obsessive-Compulsive Disorder (OCD) With Exposure and Response Prevention (EX/RP)|
|Principal investigator||H Blair Simpson, MD, PhD|
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