High-field Brain Magnetic Resonance Spectroscopy
This trial is active, not recruiting.
|Sponsor||University of Minnesota - Clinical and Translational Science Institute|
|Collaborator||National Institute for Biomedical Imaging and Bioengineering (NIBIB)|
|Start date||November 2012|
|End date||November 2017|
|Trial size||30 participants|
|Trial identifier||NCT02053701, 1210M23141, P41EB015894|
Magnetic resonance spectroscopy (MRS) allows non-invasive measurement of the concentration of up to 18 metabolites in the brain ("neurochemical profile").
The objective of this proposal is to develop new methods for high-field brain MRS (3 to 7 Tesla).
Our main hypothesis is that higher magnetic fields lead to improved spatial and temporal resolution and improved quantification precision.
1. To obtain improved "neurochemical profiles" in the brain using single voxel proton MRS at very high field (3 Tesla to 7 Tesla).
2. To develop new methods for proton magnetic resonance spectroscopic imaging (MRSI) to obtain metabolic maps at very high field (3 Tesla to 7 Tesla).
Since this project is focused on technical development, only healthy volunteers will be recruited (no patients).
Precision of quantification of brain metabolites concentrations
time frame: One time only
Male or female participants at least 18 years old.
Inclusion Criteria: - over 18 years old Exclusion Criteria: - no metallic implant or other MRI-incompatible device
|Official title||Technical Developments for High-field Brain Magnetic Resonance Spectroscopy|
|Principal investigator||Pierre-Gilles Henry, PhD|
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