Minocycline to Reduce Pain After Carpal Tunnel Release
This trial is active, not recruiting.
|Conditions||chronic pain, post-operative pain|
|Sponsor||VA Palo Alto Health Care System|
|Start date||January 2012|
|End date||April 2014|
|Trial size||80 participants|
|Trial identifier||NCT02051296, RX000487|
The investigators are looking at whether peri-operative minocycline will reduce the duration of pain after minor hand surgery: carpal tunnel release and trigger finger release.
The investigators' hypothesis is that minocycline will reduce post-operative pain.
|Endpoint classification||efficacy study|
|Intervention model||parallel assignment|
|Masking||double blind (subject, caregiver, investigator, outcomes assessor)|
perioperative minocycline for 5 days, starting 2 hours prior to surgery then 100mg BID
time to pain resolution
time frame: 1 year
Male or female participants at least 18 years old.
Inclusion Criteria: - Adult, Veteran, Exclusion Criteria: - Kidney failure, Liver failure, thrombocytopenia, ALS, SLE, Frailty, unable to understand survery
|Official title||A Trial of Minocycline for Pain After Carpal Tunnel and Trigger Release|
|Principal investigator||Catherine Curtin, MD|
|Description||This is a double blinded randomized controlled trial. Patients are given 100mg of minocycline 2 hours prior to their procedure and then 100mg two times a day for 5 days. The subjects are then contacted daily to check their level of pain. The investigators' outcome of interest is time to pain resolution. The investigators will perform a futility analysis to assess if a larger trial would be a reasonable next step after this pilot study.|
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