This trial is active, not recruiting.

Conditions chronic pain, post-operative pain
Treatments minocycline, placebo
Phase phase 2
Sponsor VA Palo Alto Health Care System
Start date January 2012
End date April 2014
Trial size 80 participants
Trial identifier NCT02051296, RX000487


The investigators are looking at whether peri-operative minocycline will reduce the duration of pain after minor hand surgery: carpal tunnel release and trigger finger release.

The investigators' hypothesis is that minocycline will reduce post-operative pain.

United States No locations recruiting
Other Countries No locations recruiting

Study Design

Allocation randomized
Endpoint classification efficacy study
Intervention model parallel assignment
Masking double blind (subject, caregiver, investigator, outcomes assessor)
Primary purpose prevention
perioperative minocycline for 5 days, starting 2 hours prior to surgery then 100mg BID
RCT blinded placebo trial
(Placebo Comparator)

Primary Outcomes

time to pain resolution
time frame: 1 year

Eligibility Criteria

Male or female participants at least 18 years old.

Inclusion Criteria: - Adult, Veteran, Exclusion Criteria: - Kidney failure, Liver failure, thrombocytopenia, ALS, SLE, Frailty, unable to understand survery

Additional Information

Official title A Trial of Minocycline for Pain After Carpal Tunnel and Trigger Release
Principal investigator Catherine Curtin, MD
Description This is a double blinded randomized controlled trial. Patients are given 100mg of minocycline 2 hours prior to their procedure and then 100mg two times a day for 5 days. The subjects are then contacted daily to check their level of pain. The investigators' outcome of interest is time to pain resolution. The investigators will perform a futility analysis to assess if a larger trial would be a reasonable next step after this pilot study.
Trial information was received from ClinicalTrials.gov and was last updated in May 2014.
Information provided to ClinicalTrials.gov by VA Palo Alto Health Care System.