High Resolution Magnetic Resonance Imaging in Patients With Brain Tumors
This trial is active, not recruiting.
|Sponsor||University of Texas Southwestern Medical Center|
|Collaborator||National Cancer Institute (NCI)|
|Start date||August 2009|
|End date||January 2018|
|Trial size||184 participants|
|Trial identifier||NCT02035852, 1R01CA154843-01A1, STU 062010-160|
The study will compare two different size MRI's of a brain tumor.
Benefit of 7T MR imaging
time frame: Baseline and 6 month intervals after baseline
time frame: Every 6 months, up to 12 months.
Male or female participants at least 18 years old.
Inclusion Criteria: - Male or female, age 18 years or older - Patient must meet at least one of the four following criteria regarding brain tumor diagnosis: - Histological diagnosis of a brain tumor - Histological diagnosis of systemic cancer and brain MR imaging suggestive of metastatic disease to the brain - Pre-operative brain MR imaging suggestive of a brain tumor - Radiographic diagnosis of brain tumor in an inoperable location (e.g., brainstem) - Patient able and willing to provide informed consent - Karnofsky Performance status > 70% - Life expectancy greater than 3 months - Negative serum or urine pregnancy test or child bearing potential terminated by surgery, radiation, menopause or current use of two approved methods of birth control - Patients who are excluded from 7T MR imaging because of titanium implants that are not yet established to be safe at 7T remain eligible for the imaging at 3T * Spanish speaking participants will be enrolled for this study Exclusion Criteria: - Body weight >137 Kg (300 lbs) - Patient unable to provide informed consent - Karnofsky Performance status < 70% - Patients who are claustrophobic or have other contraindications to MRI, such as implanted pacemaker device vascular clips, surgical clips, prosthetic valves, pacemakers, otologic implants - NYHA class III and IV congestive heart failure - Psychiatric or addictive disorders that preclude obtaining informed consent - Unstable angina - Sexually active patients of childbearing potential not using a reliable contraceptive method - Pregnant or lactating women - Women of childbearing potential who refuse a pregnancy test (performed during screening)
|Official title||High Resolution Magnetic Resonance Imaging in Patients With Brain Tumors|
|Principal investigator||Elizabeth Maher, MD|
|Description||The study is designed to directly compare the MR images of a brain tumor obtained on the 3T and then 7T MRI in approximately 150 patients followed serially with MR imaging to evaluate for tumor progression.|
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