This trial is active, not recruiting.

Condition breast cancer
Treatments everolimus, exemestane
Phase phase 2
Targets mTOR, FKBP-12
Sponsor Jules Bordet Institute
Collaborator Novartis
Start date January 2014
End date October 2016
Trial size 130 participants
Trial identifier NCT02028364, 2012-004860-22, IJB-BCTL:20120306


This is a prospective, single arm trial in which patients with locally advanced or metastatic endocrine receptor positive and HER2 negative breast cancer refractory to non-steroidal aromatase inhibitors (NSAI) will receive Everolimus 10mg orally daily given in conjunction with exemestane 25mg orally daily until disease progression or treatment discontinuation for any other reasons. Tumour, metastatic lesions and blood samples will be collected during the treatment period. Genomic analysis on metastatic tumour tissue specimens and "liquid biopsies" will help to identify patients who benefit of this treatment regimen. The main objective is to evaluate if early metabolic response (MR) using FDG-PET/CT is associated with progression free survival (PFS) this population.

United States No locations recruiting
Other countries No locations recruiting

Study Design

Endpoint classification safety/efficacy study
Intervention model single group assignment
Masking open label
Primary purpose treatment
Everolimus 10mg orally daily given in conjunction with exemestane 25mg orally daily until disease progression or treatment discontinuation for any other reasons.
everolimus Afinitor
10mg orally daily
exemestane Aromasin, Exemestane Teva, Exemestane Sandoz, Exemarom,Exemestane Mylan, Exemestane Accord Healthcare
25mg orally daily

Primary Outcomes

Progression Free Survival (PFS)
time frame: 2.5 years from FPI

Secondary Outcomes

overall survival(OS)
time frame: 2.5 years from first patient in
Occurence of Adverse events
time frame: from the signature of informed consent until until the end of study treatment/treatment discontinuation visit 28 days after the last dose of study medication
Metabolic response assessed by FDG PET
time frame: Baseline, day 14, Day 28 and at progression
Biomarker Assessment
time frame: baseline,day14,day28, every 8 weeks and at progression

Eligibility Criteria

Female participants at least 18 years old.

Inclusion Criteria: - Adult women (≥18 years of age) with locally advanced or metastatic breast cancer not amenable to curative treatment by surgery or radiotherapy. - Histological or cytological confirmation of estrogen-receptor positive (ER+), HER2 negative breast cancer. - Postmenopausal female defined as: - Age ≥55 years and one year or more of amenorrhoea - Age <55 years and one year or more of amenorrhoea, with an estradiol assay <20pg/ml - Surgical menopause with bilateral oophorectomy - Breast cancer that is refractory to non-steroidal aromatase inhibitors (NSAI) (i.e. anastrozole or letrozole) defined as: - Recurrence while on, or within 12 months of end of adjuvant treatment with anastrozole or letrozole; OR - Progression while on, or within one month of end of anastrozole or letrozole or treatment for locally advanced or metastatic breast cancer. - FDG-PET measurable disease defined as: at least one target lesion fulfilling following criteria: - Size ≥1.5cm; AND - FDG-PET avid lesion with uptake above the background liver uptake as described below: - i.e. with a marked accumulation of FDG, at least 1.5-fold greater than liver SUV mean + 2 SDs (in 3cm spherical ROI in normal right lobe of liver). If liver is abnormal, target lesion should have uptake > 2.0 x SUV mean of blood pool in 1cm diameter ROI in descending thoracic aorta) - The patient must have at least 1 PET-CT measurable lesion also measurable according to RECIST 1.1 criteria. - Radiological or clinical evidence of recurrence or progression on last systemic therapy prior to enrolment. - Adequate bone marrow and coagulation function as shown by: - Haemoglobin (HgB) ≥9.0 g/dL - ANC ≥1,500/mm3 (≥1.5 x 109/L) - Platelets ≥100,000/mm3 (≥100x 109/L) - INR ≤2.0 - Adequate liver function as shown by: - Alanine aminotransferase (ALT) and aspartate aminotransferase (AST) ≤2.5xULN (or ≤5 if hepatic metastases are present) - Total serum bilirubin ≤1.5 x ULN (≤3 ULN for patients known to have Gilbert Syndrome) - Adequate renal function as shown by Serum creatinine ≤1.5 x ULN - Fasting serum cholesterol, triglycerides and glucose - Fasting serum cholesterol ≤300 mg/dL or 7.75 mmol/L - Fasting triglycerides ≤2.5 x ULN - Fasting glucose < 1.5 x ULN - Eastern Co-operative Oncology Group (ECOG) performance status ≤ 2. - Written and signed informed consent obtained before any trial related activity. - Availability of a FFPE core of primary breast tumor - Possibility to obtain blood samples for the translational research studies. - For patients with accessible metastatic lesions, possibility to obtain biopsy (FFPE and frozen) of a metastatic lesion Exclusion criteria: - HER2-overexpressing patients by local laboratory testing (IHC 3+ staining or in situ hybridization positive). - Patients with only non-measurable lesions by FDG-PET (e.g. pleural effusion, ascites etc.). - Symptomatic visceral disease for example liver, pulmonary metastases or lymphangitis carcinomatosis. - Known hypersensitivity to mTOR inhibitors, e.g. sirolimus (rapamycin). - Another malignancy within 5 years prior to enrolment, with the exception of adequately treated in-situ carcinoma of the cervix, uteri, basal or squamous cell carcinoma or non-melanomatous skin cancer. - Radiotherapy within four weeks prior to enrolment except in case of localized radiotherapy for analgesic purpose or for lytic lesions at risk of fracture, which can then be completed within two weeks prior to enrolment. Patients must have recovered from radiotherapy toxicities prior to enrolment. - Currently receiving hormone replacement therapy, unless discontinued prior to enrolment. - History of symptomatic brain metastases or other central nervous system metastases. - Patients receiving concomitant immunosuppressive agents or chronic corticosteroid use at the time of study entry except in cases outlined below: - Topical applications (e.g. rash) - Inhaled sprays (e.g. obstructive airways disease) - Eye drops - Local injections (e.g. intra-articular) - Stable low dose of corticosteroids for at least two weeks before enrolment - Patients with known HIV seropositivity. Screening for HIV infection at baseline is not required - Acute and chronic, active infectious disorders (except for Hepatitis B and Hepatitis C positive patients). - Active bleeding diathesis, or on oral anti-vitamin K medication (except low dose warfarin, LMWH and acetylsalicylic acid or equivalent, as long as the INR is ≤ 2.0). - Any severe uncontrolled medical conditions such as: - Unstable angina pectoris, symptomatic congestive heart failure, myocardial infarction ≤6 months prior to enrolment, uncontrolled cardiac arrhythmia - Uncontrolled diabetes as defined by fasting glucose ≥ 1.5 x ULN - Acute and chronic, active infectious disorders and non-malignant medical illnesses that are uncontrolled or whose control may be jeopardized by the complications of this study therapy. - Symptomatic deterioration of lung function - Patients being treated with drugs recognized as being strong inhibitors or inducers of the isoenzyme CYP3A (Rifabutin, Rifampicin, Clarithromycin, Ketoconazole, Itraconazoleonazole, Voriconazole, Ritonavir, Telithromycin) within the last 5 days prior to enrolment. - History of non-compliance to medical regimens. - Patients unwilling or unable to comply with the protocol. - Concurrent anti-cancer treatment in another investigational trial, including hormonal therapy, immunotherapy or targeted agents other than those administered in this study.

Additional Information

Official title Pet Imaging as a Biomarker of Everolimus Added Value in Hormone Refractory postmenopausaL Women
Principal investigator Andrea Gombos, MD
Trial information was received from ClinicalTrials.gov and was last updated in September 2016.
Information provided to ClinicalTrials.gov by Jules Bordet Institute.