This trial is active, not recruiting.

Condition hippocampal neurogenesis in cocaine addiction
Sponsor University of Texas Southwestern Medical Center
Start date June 2012
End date June 2016
Trial size 30 participants
Trial identifier NCT02028273, STU 032012-021


This study is being done to measure the number of brain cells that grow in the brain throughout our lives while determining an effective way to complete this with an MRI (Magnetic Resonance Imaging) scanner. The number of these brain cells may be affected by cocaine use. Researchers are trying to understand the long-term effects of cocaine use on the brain.

United States No locations recruiting
Other countries No locations recruiting

Study Design

Observational model cohort
Time perspective cross-sectional
Healthy control group. No history of substance abuse or dependence.
Participants actively using cocaine.
Participants who have been abstinent from cocaine use for 3-6 months.

Primary Outcomes

Assess Neural Progenitor Cells
time frame: within 3 weeks of screening physical

Secondary Outcomes

Hippocampal cerebral blood volume
time frame: within 3 weeks of screening physical

Eligibility Criteria

Male or female participants from 18 years up to 55 years old.

Inclusion Criteria: - Cocaine-dependence (patient population) or no cocaine-dependence (control population) Exclusion Criteria: - Other medical or psychiatric disorders that may effect neural functioning - Medications that may effect neural functioning

Additional Information

Official title Hippocampal Neurogenesis in Human Subjects (Pilot Study)
Principal investigator Bryon Adinoff, M.D.
Description New neurons are generated through the process of neurogenesis. Although most active during pre-natal development, neurogenesis persists throughout the human lifespan. In adulthood, neurogenesis occurs predominantly in the subgranular zone of the hippocampal dentate gyrus. A highly novel methodology using Magnetic Resonance Spectroscopy (MRS) has recently been developed to measure the formation of hippocampal newborn stem cells in the human brain. We propose to assess Neural Progenitor Cells (NPCs) in the neuropsychiatric disorder cocaine dependence, a chronic disease process associated with pathology of the hippocampus and impaired neurogenesis. In addition, we will assess other measures associated with neurogenesis, including hippocampal (dentate gyrus) cerebral blood volume (CBV) using Vascular-Space-Occupancy (VASO) Magnetic Resonance Imaging. We predict that newborn hippocampal cells [or neuronal progenitor cells (NPCs] will be attenuated in recently using cocaine-addicted participants relative to abstinent and control participants, and that these changes will be paralleled by changes in CBV. In this pilot study, we will assess for these changes in cocaine-addicted subjects who are actively using cocaine and those who are recently abstinent (three to six months) as well as age-, race-, and gender-similar control participants.
Trial information was received from ClinicalTrials.gov and was last updated in May 2015.
Information provided to ClinicalTrials.gov by University of Texas Southwestern Medical Center.