Initial Human Validation of Simultaneous Dual-Tracer Cardiac PET Imaging
This trial is active, not recruiting.
|Conditions||ischemic heart disease, myocardial infarction|
|Treatments||cardiac pet w/18f-fluorodeoxyglucose and rubidium-82, pet scan|
|Sponsor||University of Michigan|
|Start date||December 2013|
|End date||August 2014|
|Trial size||30 participants|
|Trial identifier||NCT02003456, HUM00080193|
Positron emission tomography (PET) scans can be used to evaluate whether parts of the heart muscle are alive but receiving inadequate blood supply. This study involves the use of two radiotracers that will measure whether heart muscle cell are alive and quantify the blood supply to the heart muscle.
|Endpoint classification||bio-equivalence study|
|Intervention model||single group assignment|
Equivalence of Images from Rest Rubidium-82 Perfusion PET Obtained Separately versus Simultaneously
time frame: 2 years
Equivalence of Quantitative Estimates of Global Myocardial Blood Flow using Rubidium-82 Perfusion PET Obtained Separately versus Simultaneously
time frame: 2 years
Equivalence of Images from FDG PET Obtained Separately versus Simultaneously
time frame: 2 Years
Male or female participants at least 18 years old.
Inclusion Criteria: 1. 18 years of age or older 2. Patients referred for clinically indicated positron emission tomography (PET) viability assessment with rubidium-82 rest perfusion imaging and 18F-fluorodeoxyglucose (FDG) metabolic imaging. Exclusion Criteria: 1. Need for stress perfusion imaging 2. Claustrophobia which would prevent positron emission tomography (PET) imaging. 3. Inability to lie flat with arms positioned next to the head for approximately 20 minutes. 4. Clinical instability such as uncontrolled, potentially life threatening arrhythmias or heart failure requiring mechanical support or infusions of inotropic or vasopressor agents. 5. Pregnancy
|Official title||Initial Human Validation of Simultaneous Dual-Tracer Cardiac PET Imaging|
|Principal investigator||Venkatesh L. Murthy, M.D.|
|Description||Positron emission tomography (PET) scans can be used to evaluate whether parts of the heart muscle (myocardium) are alive but receiving inadequate blood supply. This information can be helpful in identifying the best course of treatment. This type of study involves the use of two radiotracers: rubidium-82 (to measure blood flow) and 18F-fluorodeoxyglucose or FDG (to measure whether heart muscle cells are alive). Currently, each of these radiotracers is imaged at separate times, several hours apart. The purpose of this study is to evaluate methods that could allow the entire study to be performed at one time.|
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