This trial is active, not recruiting.

Condition breast cancer
Treatment imrt + ct + mr scan
Sponsor University Health Network, Toronto
Collaborator Princess Margaret Hospital, Canada
Start date March 2013
End date January 2017
Trial size 160 participants
Trial identifier NCT01999062, UHN REB 12-5181-CE


In the proposed research study, we are investigating the feasibility of integrating automated planning tools to MR images acquired using a novel MR-guided linac, for on-line adaptive radiation treatment. However, these on-line automation tools require further technical refinement and clinical validation. The goal of this research proposal is to develop an on-line MR-guided radiation therapy process for adapting breast IMRT treatment. Such an approach will provide early stage breast cancer patients timely access to high-quality adaptive treatments without exposure to additional ionizing radiation.

United States No locations recruiting
Other Countries No locations recruiting

Study Design

Endpoint classification efficacy study
Intervention model single group assignment
Masking open label
Primary purpose diagnostic
imrt + ct + mr scan

Primary Outcomes

Time between planning of Radiation treatment and the start of radiotherapy
time frame: 3 years
The effect of breathing on the position of the heart and lung in treatment plans
time frame: 3 years

Eligibility Criteria

Female participants at least 18 years old.

Inclusion Criteria: - Patients who will receive standard two-field tangential whole breast radiation therapy with dose prescription of 4240 cGy in 16 fractions, 5000 cGy in 25 fractions or 4000 cGy in 16 fractions. - Female patients with any stage of breast cancer. - Patients with prior treatment such as surgery or chemotherapy for any type of cancer. - Able to provide a written informed consent. - ≥ 18 years of age. Exclusion Criteria: - Patients who will not receive 4240 cGy in 16 fractions, 5000 cGy in 25 fractions, or 4000 cGy in 16 fractions - Males. - Patients who received partial breast radiation and not the standard dose. - Patients who are unable to provide informed consent. - < 18 years of age.

Additional Information

Official title Automated Breast Radiation Therapy Using an MR-Guided Process
Principal investigator Robert Dinniwell, M.D.
Trial information was received from ClinicalTrials.gov and was last updated in May 2016.
Information provided to ClinicalTrials.gov by University Health Network, Toronto.