Brain Connectivity in Age-Related Macular Degeneration
This trial is active, not recruiting.
|Condition||age-related macular degeneration|
|Collaborator||National Institute on Aging (NIA)|
|Start date||April 2014|
|End date||December 2018|
|Trial size||300 participants|
|Trial identifier||NCT01996215, Pro00046073, R01AG043438|
This study is to determine how cognitive deficits (e.g.,verbal fluency deficit) in patients with Age-Related Macular Degeneration (AMD) relate to specific aspects of brain and function. The study team will assess whether the "brain signatures" associated with specific cognitive deficits differ in older adults with and without AMD.
Cognitive Changes and Brain Connectivity in Age-Related Macular Degeneration
time frame: Baseline, anticipated 2 years
Male or female participants from 50 years up to 90 years old.
Inclusion Criteria: AMD - Vision loss attributable to AMD Controls - Age match (± 5 yrs) - Gender match - Education match (± 4yrs) - Normal macular exam Exclusion Criteria: AMD - Other significant eye pathology - Mod/severe dementia - Communication barrier that precludes testing Controls - Other significant eye pathology - Mod/severe dementia - Communication barrier that precludes testing MRI subset - Devices or material incompatible with 3.0 Tesla MRI - Conditions that may interfere with interpretation of fMRI (e.g. history of stroke, brain tumor or previous brain surgery; psychoactive medications; seizure disorder) - Claustrophobia - Left-handed - Body weight > 300 lbs - Pregnant women
|Official title||Cognitive Changes and Brain Connectivity in Age-Related Macular Degeneration|
|Principal investigator||Heather Whitson, MD|
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