Longitudinal Follow-up of Brown Adipose Tissue Function and Structure
This trial is active, not recruiting.
|Sponsor||Turku University Hospital|
|Start date||January 2015|
|End date||December 2017|
|Trial size||95 participants|
|Trial identifier||NCT01985503, BAT-Follow-Up, BATFOLLOWUP|
In Turku PET Centre, there have been 3 positron emission tomography studies on brown adipose tissue (BAT) activity in healthy adults. BATPET was performed between 2008 and 2009. FATBAT started in 2011 and Dixon-BAT in 2012 and they are both currently ongoing. In the current study, participants of BATPET, FATBAT and Dixon-BAT studies are recruited for a follow-up study to examine associations between obesity, cardiovascular risk factors, serum metabolic profile and BAT structure at baseline and during follow-up several years later. 43 BATPET participants will be called for follow-up in 2013 with a follow-up period of 5 years and 52 FATBAT and Dixon-BAT participants in years 2014 and 2015 with a follow-up period of 3 years. The aim of this study is to examine longitudinal associations between BAT function and structure, liver adiposity and cardiovascular risk factors at baseline and during follow-up.
Subjects were studied in 2009 and their follow-up is in 2014.
Subjects were studied in 2011 and their follow-up is in 2016.
Correlation between baseline brown adipose tissue activity according to PET imaging and serum lipoprotein concentrations at follow-up 5 years later
time frame: 5 years
Association between brown adipose tissue structure at baseline and at follow-up
time frame: 5 years
Male or female participants from 22 years up to 55 years old.
Inclusion Criteria: - All study subjects have been screened prior to acceptance in BATPET, FATBAT and Dixon-BAT studies and no screening for inclusion is required in the current study. Exclusion Criteria: - 1) Smoking 2) Blood pressure > 160/100 mmHg 3) Pregnancy or lactation 4) Medication (expected effect on study variables)
|Official title||Brown Adipose Tissue: Longitudinal Follow-up of Brown Adipose Tissue Structure and Associations With Obesity and Cardiovascular Risk Factors in Healthy Participants of Baseline PET Studies (BAT-Follow-Up)|
|Principal investigator||Juho RH Raiko, MD, PhD|
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