Overview

This trial is active, not recruiting.

Condition obesity
Sponsor Turku University Hospital
Start date January 2015
End date December 2017
Trial size 95 participants
Trial identifier NCT01985503, BAT-Follow-Up, BATFOLLOWUP

Summary

In Turku PET Centre, there have been 3 positron emission tomography studies on brown adipose tissue (BAT) activity in healthy adults. BATPET was performed between 2008 and 2009. FATBAT started in 2011 and Dixon-BAT in 2012 and they are both currently ongoing. In the current study, participants of BATPET, FATBAT and Dixon-BAT studies are recruited for a follow-up study to examine associations between obesity, cardiovascular risk factors, serum metabolic profile and BAT structure at baseline and during follow-up several years later. 43 BATPET participants will be called for follow-up in 2013 with a follow-up period of 5 years and 52 FATBAT and Dixon-BAT participants in years 2014 and 2015 with a follow-up period of 3 years. The aim of this study is to examine longitudinal associations between BAT function and structure, liver adiposity and cardiovascular risk factors at baseline and during follow-up.

United States No locations recruiting
Other Countries No locations recruiting

Study Design

Observational model cohort
Time perspective prospective
Arm
Subjects were studied in 2009 and their follow-up is in 2014.
Subjects were studied in 2011 and their follow-up is in 2016.

Primary Outcomes

Measure
Correlation between baseline brown adipose tissue activity according to PET imaging and serum lipoprotein concentrations at follow-up 5 years later
time frame: 5 years

Secondary Outcomes

Measure
Association between brown adipose tissue structure at baseline and at follow-up
time frame: 5 years

Eligibility Criteria

Male or female participants from 22 years up to 55 years old.

Inclusion Criteria: - All study subjects have been screened prior to acceptance in BATPET, FATBAT and Dixon-BAT studies and no screening for inclusion is required in the current study. Exclusion Criteria: - 1) Smoking 2) Blood pressure > 160/100 mmHg 3) Pregnancy or lactation 4) Medication (expected effect on study variables)

Additional Information

Official title Brown Adipose Tissue: Longitudinal Follow-up of Brown Adipose Tissue Structure and Associations With Obesity and Cardiovascular Risk Factors in Healthy Participants of Baseline PET Studies (BAT-Follow-Up)
Principal investigator Juho RH Raiko, MD, PhD
Trial information was received from ClinicalTrials.gov and was last updated in November 2015.
Information provided to ClinicalTrials.gov by Turku University Hospital.