Overview

This trial is active, not recruiting.

Condition bacterial infection in copd
Treatment bronchoscopy
Sponsor Fundació Institut de Recerca de l'Hospital de la Santa Creu i Sant Pau
Collaborator Instituto de Salud Carlos III
Start date June 2012
End date March 2018
Trial size 45 participants
Trial identifier NCT01976130, IIBSP-MUC-2009-20

Summary

Study hypothesis:

Chronic Obstructive Pulmonary Disease (COPD) patients with chronic bacterial colonization have lower levels of mucins and antimicrobial peptides in their airways

United States No locations recruiting
Other Countries No locations recruiting

Study Design

Intervention model single group assignment
Masking open label
Primary purpose basic science
Arm
(Experimental)
Procedure
bronchoscopy

Primary Outcomes

Measure
Mucins in sputum
time frame: Day 1

Secondary Outcomes

Measure
Antimicrobial peptides in sputum
time frame: Day 1

Eligibility Criteria

Male or female participants at least 18 years old.

Inclusion Criteria: - COPD Exclusion Criteria: - Acute exacerbation in the last 4 weeks

Additional Information

Official title Mechanisms of Lung Defense and Their Relationship With Airway Infection in Chronic Obstructive Pulmonary Disease (COPD)
Description Main objective: (1) To investigate the expression of mucins and antimicrobial peptides in patients with severe COPD and their relationship with the presence of bacteria in the airway
Trial information was received from ClinicalTrials.gov and was last updated in September 2016.
Information provided to ClinicalTrials.gov by Fundació Institut de Recerca de l'Hospital de la Santa Creu i Sant Pau.