This trial is active, not recruiting.

Condition pulmonary disease, chronic obstructive (copd)
Treatment enose
Sponsor Fundació Institut de Recerca de l'Hospital de la Santa Creu i Sant Pau
Start date June 2012
End date December 2018
Trial identifier NCT01976117, IIBSP-ENO-2009-21


Hypothesis: A commercial e-nose (Cyranose 320) is able to detect specific breathprints from patients with COPD and bacterial infection

United States No locations recruiting
Other countries No locations recruiting

Study Design

Intervention model single group assignment
Masking open label

Primary Outcomes

Breathprint in exhaled breath from patients with COPD
time frame: Day 1

Secondary Outcomes

Breathprint in exhaled breath from COPD patients with bacterial colonization
time frame: Day 1

Eligibility Criteria

Male or female participants at least 18 years old.

Inclusion Criteria: - COPD patients Exclusion Criteria: - Exacerbation in the last 4 weeks

Additional Information

Official title E-nose Utility in the Diagnosis of Bacterial Infection in Chronic Obstructive Pulmonary Disease (COPD)
Description Thirty to 50% of COPD patients have airway colonization with potentially pathogenic bacteria. This is associated with worse prognosis. Currently, diagnosis of bacterial colonization relies mainly upon quantitative sputum culture. However, this method lacks good sensitivity. The electronic nose is a novel device made up of nanosensors capable of detecting specific volatile organic compounds (VOCs). OBJECTIVES: Main 1) To assess the usefulness of the electronic nose in the diagnosis of bacterial colonization in COPD. Secondary 1) To define the VOCs pattern associated with bacterial colonization. 2) To study the pattern of pulmonary and systemic inflammation associated with bacterial colonization as well its relationship with the aforementioned VOCs patterns.
Trial information was received from ClinicalTrials.gov and was last updated in September 2016.
Information provided to ClinicalTrials.gov by Fundació Institut de Recerca de l'Hospital de la Santa Creu i Sant Pau.