Perineural Dexmedetomidine and Femoral Nerve Block
This trial is active, not recruiting.
|Conditions||onset and duration of sensory and motor block of femoral nerve,, visual analogue pain scores,, time to first request of rescue analgesics,, total morphine consumption in 24 hours|
|Treatment||peri-neural dexmedetomidine as adjuvant to bupivacaine in femoral nerve block|
|Start date||August 2013|
|End date||December 2013|
|Trial size||45 participants|
|Trial identifier||NCT01964040, N-38-2013|
The duration of sensory block after single dose of long acting local anesthetics is not sufficient to avoid the postoperative use of opioids. Alpha-2 adrenoceptor agonists such as clonidine have been shown to increase the duration of peripheral nerve block. Dexmedetomidine is a more potent and selective α-2-adrenoceptor compared to clonidine. To the best of our knowledge, the use of Dexmedetomidine as adjuvant to local anesthetic was not previously reported for femoral nerve block.
|Endpoint classification||efficacy study|
|Intervention model||parallel assignment|
|Masking||double blind (subject, caregiver, investigator, outcomes assessor)|
|Primary purpose||supportive care|
The primary outcome measure of this study will be the change of sensory block over time.
time frame: intraoperatively every 5 minutes for the first 30 minutes of the operation, then postoperatively every 2 hours for 24hours
onset of motor and sensory block
time frame: up to 30 minutes after the end of injection
Male or female participants from 18 years up to 45 years old.
Inclusion Criteria: - all patients with ASA physical status I or II, scheduled for diagnostic knee arthroscopy Exclusion Criteria: - Patients who are refusing regional block, patients with diabetic peripheral neuropathy, renal or hepatic dysfunction, inflammation or infection at the puncture site, and history of allergic reaction to study medications
|Official title||Perineural Dexmedetomidine as an Adjuvant to Bupivacaine-induced Ultrasound-guided Femoral Nerve Block.|
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