Overview

This trial has been completed.

Condition healthy
Treatments sodium nitrate, beetroot juice
Sponsor Swiss Paraplegic Centre Nottwil
Collaborator University of Zurich
Start date June 2013
End date June 2016
Trial size 21 participants
Trial identifier NCT01961427, 2013‐12

Summary

It was shown by some researchers that dietary nitrate such as beet root juice can lower oxygen consumption in men and act as a performance enhancing supplement.

It was not shown, what the optimal dosage is and if there is any difference in oxygen consumption comparing beet root juice and inorganic nitrate.

Therefore, the aim of the study is to conduct a study ingesting different sodium nitrate and beet root juice dosages. We would measure nitrate and nitrite concentrations in the blood at different time points and the subjects have to perform an exercise test measuring oxygen consumption 3 hours after the ingestion of nitrate.

United States No locations recruiting
Other Countries No locations recruiting

Study Design

Allocation randomized
Endpoint classification efficacy study
Intervention model factorial assignment
Masking double blind (subject, caregiver, outcomes assessor)
Primary purpose treatment
Arm
(Active Comparator)
Ingestion of a solution of inorganic nitrate, dosage: 12mmol
sodium nitrate Inorganic nitrate
Ingestion of 3mmol, 6mmol and 12mmol sodium nitrate
(Active Comparator)
ingestion of inorganic nitrate (6mmol solution)
sodium nitrate Inorganic nitrate
Ingestion of 3mmol, 6mmol and 12mmol sodium nitrate
(Active Comparator)
ingestion of inorganic nitrate (3mmol solution)
sodium nitrate Inorganic nitrate
Ingestion of 3mmol, 6mmol and 12mmol sodium nitrate
(Active Comparator)
Ingestion of water as a placebo
sodium nitrate Inorganic nitrate
Ingestion of 3mmol, 6mmol and 12mmol sodium nitrate
(Active Comparator)
ingestion of 170ml of concentrated beetroot juice (12mmol)
beetroot juice Biotta beetroot juice shot
concentrated beetroot juice (dosage 3mmol, 6mmol and 12mmol)
(Active Comparator)
ingestion of 85ml concentrated beetroot juice (6mmol)
beetroot juice Biotta beetroot juice shot
concentrated beetroot juice (dosage 3mmol, 6mmol and 12mmol)
(Active Comparator)
Ingestion of 42.5ml of concentrated beetroot juice (3mmol)
beetroot juice Biotta beetroot juice shot
concentrated beetroot juice (dosage 3mmol, 6mmol and 12mmol)

Primary Outcomes

Measure
oxygen consumption
time frame: 30min

Secondary Outcomes

Measure
Blood pressure
time frame: 6 hours
oxygen saturation
time frame: 6 hours
Rating of perceived exertion (RPE)
time frame: during the 7 weeks of study phase
Heart rate
time frame: during the 7 weeks of study phase
Nitrate and nitrite concentration
time frame: 6 hours

Eligibility Criteria

Male participants from 18 years up to 45 years old.

Inclusion Criteria: - age 18 to 45 - healthy active men - non-smoking Exclusion Criteria: - medication intake during study phase

Additional Information

Official title Dose and Response of Dietary and Inorganic Nitrate in Healthy and Active Men
Principal investigator Claudio Perret, Dr. sc. nat.
Description 1. The subjects have to ingest 7 different dosages of either beetroot juice or sodium nitrate on seven different occasions. Every hour a blood withdrawal is taken to measure nitrate and nitrite concentration in the blood. 2. The subjects have to ingest 7 different dosages of either beetroot juice or sodium nitrate on seven different occasions. Three hours after the intake of the supplement the subjects have to perform an exercise test on a bicycle. They have to cycle 5 min at 50% of maximal oxygen consumption and 8min at 80% of maximal oxygen consumption separated by a 5min break. Oxygen consumption would be measured during the whole exercise test. Blood withdrawal is taken before the ingestion, after 3 hours and after the test.
Trial information was received from ClinicalTrials.gov and was last updated in November 2016.
Information provided to ClinicalTrials.gov by Swiss Paraplegic Centre Nottwil.