Circumferential Section Pane Less Than 1 mm in Esophagectomy for Esophageal Cancer.
This trial is active, not recruiting.
|Sponsor||University Hospital, Gasthuisberg|
|Start date||July 2013|
|End date||December 2013|
|Trial size||923 participants|
|Trial identifier||NCT01959906, CRM<1mm|
A suspicious circumferential resection margin (CRM), defined as tumor cells within 1 mm of the CRM, is still controversial. The aim of this study was to compare the clinical significance of a suspicious CRM to histologically positive (R1) and negative margin (R0) resections in patients with pT3 esophageal and GE-Junction tumors.
Incomplete resection, microscopical tumor residu left behind
complete resection (R0), however tumor spreads till less than 1 mm from the section pane.
time frame: 5 years after esophagectomy
Male or female participants from 18 years up to 95 years old.
Inclusion Criteria: - pathologic T3 tumours of esophagus or GEJ Exclusion Criteria: - pT other than pT3 - R2 resections
|Official title||Prognostic Value of a Circumferential Section Pane Less Than 1 mm in Esophagectomy for Esophageal Cancer.|
|Principal investigator||Katrien Van de Steen, MSc|
|Description||From our prospectively build database 923 consecutive pT3 patients operated between january 1990 and june 2013 were selected. CRM status in patients treated by surgery only (n = 747) or after neoadjuvant therapy (n = 176) was recorded prospectively after surgery. Kaplan-Meier survival curves were generated, and factors affecting survival were assessed by Cox regression multivariate analysis.|
Call for more information