This trial is active, not recruiting.

Condition esophageal cancer
Sponsor University Hospital, Gasthuisberg
Start date July 2013
End date October 2013
Trial size 650 participants
Trial identifier NCT01958697, AG-BMI


Esophagectomy for cancer is often accompanied with severe preoperative weight loss. Body Mass Index (BMI) values are age-independent and the same for both sexes. From the perspective that these two parameters should actually be taken into account too, we developed a model to calculate "age-gender specific BMI-percentiles" (AG-BMI) and tested this model in relation to survival outcome after esophagectomy for cancer.

United States No locations recruiting
Other Countries No locations recruiting

Study Design

Observational model cohort
Time perspective retrospective
Patients who's peroperative BMI is less than the 10th centile
Patients who's peroperative BMI equals or is greater than the 10th centile

Primary Outcomes

Overall 5 year survival
time frame: 5 years after esophagectomy

Eligibility Criteria

Male or female participants from 18 years up to 95 years old.

Inclusion Criteria: - any type of esophagectomy Exclusion Criteria: - Preoperative organ metastasis (cM+ or yM+) - esophageal bypass surgery

Additional Information

Official title Age and Gender Corrected Body Mass Index: When Preoperative Weight Loss and Underweight Are Becomming Clinically Significant in Esophagectomy for Cancer.
Description Age-Gender specific BMI percentiles are more accurate compared to the current BMI classes in predicting Overall Survival (OS) after esophagectomy for cancer. Furthermore we believe in a more devastating impact on OS from underweight and not from overweight. By preoperatively identifying risk patients for poorer OS, especially the non-tumoral deaths, this can be a tool to tailor postoperative nutritional strategies to counter further weight loss and bringing postoperative weight to normal ranges.
Trial information was received from ClinicalTrials.gov and was last updated in October 2013.
Information provided to ClinicalTrials.gov by University Hospital, Gasthuisberg.