Influence of Intrauterine Growth Restriction on Amplitude-integrated EEG in Preterm Infants
This trial is active, not recruiting.
|Conditions||intrauterine growth restriction, premature - weight 1000g-2499g or gestation of 28-37weeks, neurodevelopmental disorder, eeg; spikes, centrotemporal, epilepsy of childhood|
|Sponsor||Medical University of Vienna|
|Start date||June 2010|
|End date||September 2013|
|Trial size||156 participants|
|Trial identifier||NCT01942525, KKS-07-2013|
Objective: The impact of intrauterine growth restriction (IUGR) on perinatal morbidity and long-term neurodevelopmental outcome has been published in numerous studies. Throughout this analysis, the influence of IUGR on the postnatal amplitude-integrated EEG (aEEG) in preterm infants below 30 weeks of gestation was assessed. The second concern was the correlation between the pattern of the aEEG in the first two weeks with neurodevelopmental outcome, comparing infants with and without IUGR.
Methods: Routinely assessed aEEG data of preterm infants with IUGR born below 30 weeks of gestation in the years 2005 until 2007 were analysed retrospectively according to the aEEG score (combining occurrence of sleep-wake-cycles, background activity and suspected seizure activity). Neurodevelopmental outcome was evaluated at 24 months using the Bayley Scales of Infant Development and standardized neurologic examination.
aEEG score (including background pattern, occurrence of sleep-wake-cycling and presence of seizure activity)
time frame: first 14 days of life
time frame: 24 months
Male or female participants from 23 weeks up to 30 weeks old.
Inclusion Criteria: - preterm infants below 30 weeks of gestation Exclusion Criteria: - congenital anomalies - severe asphyxia
|Official title||Intrauterine Growth Restriction Has an Impact on Amplitude-integrated EEG in Preterm Infants|
|Principal investigator||Katrin Klebermass-Schrehof, MD|
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