This trial is active, not recruiting.

Condition stroke
Treatment transcranial magnetic stimulation (tms)
Sponsor Kessler Foundation
Start date February 2013
End date September 2016
Trial size 12 participants
Trial identifier NCT01938690, R-758-12


Approximately two thirds of stroke survivors have profoundly impaired function of the upper limb. Currently the main stay of the treatment for upper limb motor function is rehabilitation therapy focusing on repetitive and skillful task practice (task-oriented therapy) which has been shown to induce substantial functional reorganization in the undamaged motor cortex and functional recovery. In spite of rehabilitation therapy, functional recovery of arm and hand function is limited to one third of stroke survivors and there is a great need for adjunct treatment to current practice. Repetitive Transcranial Magnetic Stimulation (rTMS) is a noninvasive means of stimulating nerve cells in superficial areas of the brain and emerging as a novel method of modulating cortical excitability and promoting functional recovery after stroke. There have been studies using rTMS to improve motor function after stroke. However, whether 1Hz rTMS can enhance the effect of the task-oriented therapy on upper limb function after stroke has not been investigated. In this pilot proposal, we intend to investigate the feasibility of 1Hz rTMS on unaffected hemisphere as an adjunct to task-oriented therapy to improve upper limb motor function among stroke patients. The information obtained from this pilot study will provide a platform for the future randomized control trials combining the rTMS and task-oriented therapy to enhance motor recovery among stroke survivors.

United States No locations recruiting
Other Countries No locations recruiting

Study Design

Allocation randomized
Endpoint classification efficacy study
Intervention model parallel assignment
Masking double blind (subject, outcomes assessor)
Primary purpose treatment
(Sham Comparator)
Sham stimulation on the scalp of unaffected brain
transcranial magnetic stimulation (tms)
8 sessions of TMS followed by task specific training
transcranial magnetic stimulation on unaffected brain
transcranial magnetic stimulation (tms)
8 sessions of TMS followed by task specific training

Primary Outcomes

Upper limb function (Fugl Meyer score)
time frame: 6 months

Eligibility Criteria

Female participants at least 18 years old.

Inclusion Criteria: --≥18 years of age - Ability to give informed consent - An unilateral ischemic stroke of onset 6-36 months prior to the study - No other known brain abnormalities by medical history or by MRI - Affected upper limb function of score 2-6 in Chedoke Arm and Hand Inventory - Enrolled or planned to be enrolled in occupational therapy at Kessler Institute for Rehabilitation as an outpatient Exclusion Criteria: - More than one stroke (Transient Ischemic Attack not a reason for exclusion) Neurological conditions other than stroke (brain tumor, Parkinson's disease, etc) - History of epilepsy or unprovoked seizures - Family history of epilepsy (father, mother, children, siblings with diagnosis of epilepsy) - Implanted medical devices (pacemakers, defibrillators, medical pump, implanted brain stimulator, aneurysm clip, carotid or cerebral stents, central venous catheter, cochlear implant, internal hearing aids) - Damaged skin or skull of head - Excessive spasticity of upper limb as indicated by Modified Ashworth Spasticity Scale >2/4 - Recent injection of antispastic medications (Botulinum toxin, phenol) of the last 3 months or scheduled such injection during the study period - Severe sensory deficits as measured by a score of 2 on item 8 of the National Institute of Health (NIH) stroke scale - Severe aphasia as measured by a score of ≥2 on item 9 of NIH stroke scale - Being determined to be medically unstable by a physician - Being pregnant or trying to become pregnant - Past or current alcohol abuse, illicit drug use, or significant mental illness (schizophrenia, major depression, manic disorders) - Working with metal currently or in the past - Tattoo with metal based ink on the head or neck - Unable to answer the questionnaires in the consent form correctly

Additional Information

Official title Effect of Transcranial Magnetic Stimulation on Motor Recovery of Upper Limb Among Stroke Survivors: Pilot Study
Trial information was received from ClinicalTrials.gov and was last updated in February 2016.
Information provided to ClinicalTrials.gov by Kessler Foundation.