Overview

This trial is active, not recruiting.

Conditions abdominal aortic aneurysm, coronary heart disease nos, unheralded corronary death, intracerebral haemorrhage, heart failure, ischemic stroke, myocardial infarction, stroke, peripheral arterial disease, stable angina pectoris, subarachnoid haemorrhage, transient ischemic attack, unstable angina, cardiac arrest, sudden cardiac death
Treatment no treatment
Sponsor University College, London
Collaborator Wellcome Trust
Start date January 2012
End date December 2013
Trial size 1937360 participants
Trial identifier NCT01937065, 12_153R_IP4

Summary

Study of heterogeneity in associations between social deprivation and the initial presentation of 12 cardiovascular diseases.

United States No locations recruiting
Other Countries No locations recruiting

Study Design

Observational model cohort
Time perspective retrospective
Arm
no treatment

Primary Outcomes

Measure
Hazard ratios for the associations between social deprivation and initial presentation of 12 cardiovascular diseases.
time frame: Followed for the duration of general practice registration between January 1997 and March 2010, an expected average of 5 years

Secondary Outcomes

Measure
Lifetime cumulative incidence per quintile of social deprivation
time frame: Followed for the duration of general practice registration between January 1997 and March 2010, an expected average of 5 years

Eligibility Criteria

Male or female participants at least 30 years old.

Inclusion Criteria: - One year prior to study entry (up-to-standard follow-up, CPRD quality research standard). - 30 years or older - Recorded sex - Free of symptomatic CVD at inclusion. Exclusion Criteria: - Pregnant women in the 6 months before the eligibility date

Additional Information

Description This study is part of the CALIBER (Cardiovascular disease research using linked bespoke studies and electronic records) programme funded over 5 years from the NIHR and Wellcome Trust. The central theme of the CALIBER research is linkage of the Myocardial Ischaemia National Audit Project (MINAP) with primary care (GPRD) and other resources. The overarching aim of CALIBER is to better understand the aetiology and prognosis of specific coronary phenotypes across a range of causal domains, particularly where electronic records provide a contribution beyond traditional studies. CALIBER has received both Ethics approval (ref 09/H0810/16) and ECC approval (ref ECC 2-06(b)/2009 CALIBER dataset).
Trial information was received from ClinicalTrials.gov and was last updated in September 2013.
Information provided to ClinicalTrials.gov by University College, London.