This trial is active, not recruiting.

Condition intrahepatic cholangiocarcinoma
Treatment surgical treatment
Sponsor First Affiliated Hospital, Sun Yat-Sen University
Collaborator Guangdong Province, Department of Science and Technology
Start date October 2012
End date December 2013
Trial size 20 participants
Trial identifier NCT01917370, k0113011-2013ICC


The investigators study the VEGF signaling in ICC cell lines/human tissues and its mechanism in HCC growth, proliferation and apoptosis.

United States No locations recruiting
Other Countries No locations recruiting

Study Design

Observational model case control
Time perspective prospective
patients with intrahepatic cholangiocarcinoma treated by surgical treatment
surgical treatment hepatectomy
all the patients in the study must have been treated by the surgery at the first time and have been confirmed as 'complete section' by the post-surgery radiological image.

Primary Outcomes

the variation of the quantity of VEGF signal pathway genes in normal liver tissue,peri tumor,tumor and metastasis.
time frame: the day when conducting surgery (day 1)

Eligibility Criteria

Male or female participants from 16 years up to 90 years old.

Inclusion Criteria: 1. hepatocellular patients diagnosed through biopsy;or either dynamic imagine with a diagnosis of intrahepatic cholangiocarcinoma and CA199>100U/L;or two or more dynamic imagine with a diagnosis of intrahepatic cholangiocarcinoma 2. Child-Pugh A or B 3. well preserved renal and hematopoietic Function 4. receive complete surgical therapy 5. achieve complete section accessed by contrast-enhanced CT Exclusion Criteria: 1. incomplete section 2. Child-Pugh C 3. combination with other hepatobiliary disease 4. suffer from other tumors concurrently or in last five years

Additional Information

Official title VEGF Signaling Promotes Cell Growth and Metastasis in Intrahepatic Cholangiocarcinoma in a VEGF
Principal investigator Ming Kuang, MD
Description Several studies have documented the elevated expression of VEGF and its receptors in ICC cell lines and tumor tissues. Another study observed that the elevation of VEGF promotes the growth. Clinical analyses have discovered the high expression of VEGF is correlated with tumor progression, vascular invasion, distal metastasis and poor prognosis. However, few studies have been conducted to investigate the VEGF signaling in ICC cells and its possible mechanism in regulating ICC growth.Therefore,we try to clarify the mechanism of VEGF signal in ICC growth,proliferation and apoptosis.
Trial information was received from ClinicalTrials.gov and was last updated in August 2013.
Information provided to ClinicalTrials.gov by First Affiliated Hospital, Sun Yat-Sen University.