VEGF Signaling Promotes Cell Growth and Metastasis in Intrahepatic Cholangiocarcinoma in a VEGF Receptor Mediated Pathway
This trial is active, not recruiting.
|Sponsor||First Affiliated Hospital, Sun Yat-Sen University|
|Collaborator||Guangdong Province, Department of Science and Technology|
|Start date||October 2012|
|End date||December 2013|
|Trial size||20 participants|
|Trial identifier||NCT01917370, k0113011-2013ICC|
The investigators study the VEGF signaling in ICC cell lines／human tissues and its mechanism in HCC growth, proliferation and apoptosis.
|Observational model||case control|
the variation of the quantity of VEGF signal pathway genes in normal liver tissue,peri tumor,tumor and metastasis.
time frame: the day when conducting surgery (day 1)
Male or female participants from 16 years up to 90 years old.
Inclusion Criteria: 1. hepatocellular patients diagnosed through biopsy;or either dynamic imagine with a diagnosis of intrahepatic cholangiocarcinoma and CA199＞100U/L；or two or more dynamic imagine with a diagnosis of intrahepatic cholangiocarcinoma 2. Child-Pugh A or B 3. well preserved renal and hematopoietic Function 4. receive complete surgical therapy 5. achieve complete section accessed by contrast-enhanced CT Exclusion Criteria: 1. incomplete section 2. Child-Pugh C 3. combination with other hepatobiliary disease 4. suffer from other tumors concurrently or in last five years
|Official title||VEGF Signaling Promotes Cell Growth and Metastasis in Intrahepatic Cholangiocarcinoma in a VEGF|
|Principal investigator||Ming Kuang, MD|
|Description||Several studies have documented the elevated expression of VEGF and its receptors in ICC cell lines and tumor tissues. Another study observed that the elevation of VEGF promotes the growth. Clinical analyses have discovered the high expression of VEGF is correlated with tumor progression, vascular invasion, distal metastasis and poor prognosis. However, few studies have been conducted to investigate the VEGF signaling in ICC cells and its possible mechanism in regulating ICC growth.Therefore,we try to clarify the mechanism of VEGF signal in ICC growth,proliferation and apoptosis.|
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