Perioperative Application of Omega-3 Polyunsaturated Fatty Acids in Gastric Cancer Patients
This trial is active, not recruiting.
|Treatment||omega-3 polyunsaturated fatty acids|
|Start date||June 2013|
|End date||December 2013|
|Trial size||100 participants|
|Trial identifier||NCT01910948, omega-3 PUFA|
To evaluate immunomodulatory effects of perioperative application of omega-3 polyunsaturated fatty acids in gastric cancer surgery, the effects of postoperative recovery, the improvement of nutritional status, incidence rate of related complications, and whether it can reduce the average postoperative hospitalization days.
|Endpoint classification||efficacy study|
|Intervention model||single group assignment|
|Masking||single blind (subject)|
|Primary purpose||supportive care|
blood immune factors
time frame: 10 days
Male or female participants from 18 years up to 85 years old.
- Patients coming to FirstJilinU diagnosed gastric cancer by endoscopy and pathology.
- No preoperative treatment, the gastric cancer radical surgery in our hospital is the first treatment.
- Nutrition screening score (NRS 3 or higher).
- Albumin and (or) immune enhancer were not used within two weeks before operation .
- No blood system diseases.
- Being in the acute phase of inflammation before operation and emergency surgery.
- Patients combined metabolic diseases such as diabetes, hyperthyroidism, immune system disease or taking immunosuppressants;
- Combined hepatic insufficiency.
- Spleen resected in operation
|Official title||Efficacy of Perioperative Application of Omega-3 Polyunsaturated Fatty Acids on Postoperative Immunization in Gastric Cancer Patients - A Prospective, Randomized Clinical Trial|
|Description||Methods: Choose from 6 to 2013-2013-12 gastric cancer patients, according to inclusion criteriaS to choose the objectS of study from the gastric cancer patients coming to our hospital 2013-06 to 2013-12 .The included patients will be randomly divided into two groups A and B, two groups of patients 4 days before operation begin to give parenteral nutrition: A: the control group of normal intravenous nutrition. B: the trial group,add Omega-3 Polyunsaturated Fatty Acids 0.2 g/kg to parenteral nutrition, no use on the day of surgery, postoperative 2 days continue to add Omega-3 Polyunsaturated Fatty Acids 0.2 g/kg. Detect and compare CRP、TNF-α、IL-1、IL-4、lL-6、 IL-8、lL-10 levels of two groups in days before parenteral nutrition and applicating 3rd day and postoperative 1st, 3rd, 5th,and detect liver function in preoperative and postoperative 2nd,5th,7th day. Record postoperative anal exhaust time, postoperative complications, postoperative hospital days, preoperative and postoperative body weight.Results: Trail group patients compared with the control group,Omega-3 Polyunsaturated Fatty Acids can reduce early postoperative inflammatory cytokines release, reduce the postoperative fever time, reduce the incidence of systemic inflammatory response syndrome, promote the recovery of gastrointestinal function, improve the nutritional state of patients, reduce infection and related complications after the surgery and reduce postoperative hospitalization days. Conclusions: Perioperative application of omega 3 PUFA can reduce the release of inflammatory cytokines, regulating cell and humoral immunity, reduce the postoperative fever time, reduce the local inflammation medium that inhibit the gastrointestinal peristalsis, promote the recovery of gastrointestinal function, improve the nutritional state of patients, thereby reducing the occurrence of postoperative infection and related complications, reduce postoperative hospitalization days.|
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