This trial is active, not recruiting.

Conditions overweight, obesity
Treatments water soluble cod protein, non-water soluble cod protein, intact cod protein, control
Sponsor University of Bergen
Collaborator Granit AS
Start date August 2013
End date December 2016
Trial size 100 participants
Trial identifier NCT01894542, 2011/572-14


The investigators have previously shown the intact protein from cod filet improves glucose homeostasis and serum lipid profile in overweight adults. A large amount of trimmings from various fish species such as cod is thrown away or sold at very low prices for animal feed, and analyses of the amino acid composition reveals that this can be a good protein source for humans. Two fractions are normally isolated from intact fish meal, i.e. water soluble and non-water soluble proteins. In the present study the investigators will compare these fractions, by studying their effects on glucose homeostasis and inflammatory markers in overweight/obese adults.

United States No locations recruiting
Other countries No locations recruiting

Study Design

Allocation randomized
Intervention model factorial assignment
Masking double blind (subject, investigator)
Primary purpose treatment
water soluble cod protein
6g protein per day for 8wk
non-water soluble cod protein
6 g protein per day for 8 wk
intact cod protein
6 g protein per day for 8wk
(Placebo Comparator)
Control group will receive tablet containing only tablet fillers (the same as in the cod protein tablets).

Primary Outcomes

Glucose tolerance
time frame: 8 wk

Secondary Outcomes

Inflammatory status in fasting state and postprandially
time frame: 8 wk

Eligibility Criteria

Male or female participants from 18 years up to 65 years old.

Inclusion Criteria: - BMI>27 - healthy Exclusion Criteria: - known diseases - medications affecting blood glucose, lipids and inflammatory status - allergies towards fish, milk, egg

Additional Information

Official title An 8 Week Study to Compare the Effects of Water Soluble and Non-water Soluble Cod Proteins on Glucose Homeostasis and Inflammatory Markers in Overweight and Obese Adults
Description Participants receive 6g per day of water soluble on non-water soluble cod protein as tablets for 8 weeks.
Trial information was received from ClinicalTrials.gov and was last updated in October 2016.
Information provided to ClinicalTrials.gov by University of Bergen.