This trial is active, not recruiting.

Conditions lung cancer, ventricular failure, right
Treatment lung resection
Sponsor University of Glasgow
Collaborator Golden Jubilee National Hospital
Start date August 2013
End date September 2014
Trial size 25 participants
Trial identifier NCT01892800, 1-shelly


The purpose of this study is explore the impact of lung cancer surgery on the function of the right side of the heart.

United States No locations recruiting
Other Countries No locations recruiting

Study Design

Observational model cohort
Time perspective prospective
Patients with suspected lung cancer undergoing lung resection by anatomic lobectomy
lung resection Pulmonary lobectomy

Primary Outcomes

Right ventricular ejection fraction
time frame: 3 days

Secondary Outcomes

Association between RVEF and contractility / loading indices
time frame: 3 days
time frame: 3 days
Association between biomarkers of myocardial and endothelial dysfunction, systemic inflammation, oxidative and nitrosative stress and ΔRVEF
time frame: 3 days
Association between RVEF and functional status
time frame: 3 months and 1 year

Eligibility Criteria

Male or female participants at least 16 years old.

Inclusion Criteria: 1. Provision of informed consent 2. Age >16 years 3. Planned elective lung resection by lobectomy Exclusion Criteria: 1. Pregnancy 2. On-going participation in any investigational research which could undermine the scientific basis of the study 3. Contraindications to magnetic resonance imaging: i. Cardiac pacemaker, artificial heart valve, neurostimulator, cochlear implant ii. Aneurysm clips iii. Metal injuries to the eye iv. Loose metal in an part of the body 4. Wedge / segmental / sub-lobar lung resection 5. Pneumonectomy 6. Isolated right middle lobectomy

Additional Information

Official title The Pulmonary Vascular / Right Ventricular Response to Lung Resection
Principal investigator Ben Shelley, MB ChB
Description Lung cancer is the second most common cancer in the UK. In suitable cases the best chance of cure is surgical resection. Studies suggest that lung resection is associated with right ventricular (RV) dysfunction, predisposing to complications and post-operative dyspnoea. Studies of RV function following lung resection have been hampered by the limitations of the techniques used. In addition the mechanism of RV dysfunction has remained elusive. In this prospective observational study the RV response to lung resection will be characterised by sequential assessment of right ventricular ejection fraction (RVEF) measured using cardiovascular magnetic resonance (CMR). CMR is non-invasive, involves no ionising radiation and due to its high spatial resolution is the gold standard for assessing RV volumes. Comprehensive CMR and echocardiographic assessment of the pulmonary vascular - RV axis will allow us to interpret peri-operative changes in RVEF in the context of RV contractility and loading indices. In addition, contemporaneous blood samples will be taken for measurement of biomarkers of myocardial and endothelial dysfunction and systemic inflammation. With increased understanding of the mechanisms involved, it may be possible to prevent RV dysfunction; reducing complication rates, hospital stay and costs and ameliorating long term dyspnoea.
Trial information was received from ClinicalTrials.gov and was last updated in May 2016.
Information provided to ClinicalTrials.gov by University of Glasgow.