Storage Temperature and Quality of Leucoreduced Whole Blood
This trial is active, not recruiting.
|Conditions||trauma, austere environment, blood bank, buddy transfusion|
|Treatment||donation of 1 whole blood unit|
|Sponsor||Haukeland University Hospital|
|Collaborator||Norwegian Armed Forces Medical Service|
|Start date||March 2013|
|End date||July 2016|
|Trial size||80 participants|
|Trial identifier||NCT01892670, 2012/2279|
In a combat situation the need for safe and high-quality blood products is increasing. WB (Whole Blood) is used in many trauma situations, but we wish to investigate whether there is an even better whole blood product.
The purpose of this study is to examine the quality of leucoreduced, cold-stored whole blood. We also wish to examine the effects of filtration of whole blood without a 1-2 hour holding-time (warm-filtration) and the effects of forced filtration. We also wish to explore the possibility of using cold-stored WB for production of RCC.
Analyses are performed with a main focus to investigate function and quality of red blood cells and platelets.
|Endpoint classification||safety/efficacy study|
|Intervention model||parallel assignment|
|Masking||single blind (subject)|
time frame: After 10 days of cold-storage
time frame: After leukocyte filtration
Male or female participants from 18 years up to 70 years old.
Inclusion Criteria: - Healthy volunteer - Age between 18 and 70 - Negative pregnancy test (women in fertile age) - Blood pressure range: (160-100)/(100-40) - Pulse range: 40-100 Exclusion Criteria: - Usage of platelet-influencing medication - Mild flu or more severe illnesses - Open wound - Pregnancy or trying to get pregnant
|Official title||Storage Temperature and Quality of Leucoreduced Whole Blood|
|Principal investigator||Geir Strandenes, MD|
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