This trial is active, not recruiting.

Condition heart failure
Treatment aerobic exercise training
Sponsor University of Sao Paulo General Hospital
Collaborator Fundação de Amparo à Pesquisa do Estado de São Paulo
Start date March 2008
End date December 2012
Trial size 34 participants
Trial identifier NCT01884142, Ergoreflex


The investigators hypothesize that exercise training would improve the mechanoreflex and metaboreflex control in heart failure patients.

United States No locations recruiting
Other countries No locations recruiting

Study Design

Allocation randomized
Intervention model parallel assignment
Masking open label
Primary purpose treatment
(No Intervention)
Control Group
Aerobic Exercise Training
aerobic exercise training

Primary Outcomes

Autonomic Control
time frame: 4 months
Muscular Evaluation
time frame: 4 months

Secondary Outcomes

Functional Capacity
time frame: 4 months
Muscle Blood Flow
time frame: 4 months
Blood Pressure
time frame: 4 months

Eligibility Criteria

Male or female participants from 30 years up to 65 years old.

Inclusion Criteria: - Patients with systolic heart failure; - New York Heart Association (NYHA) class II-III; - Left ventricular ejection fraction less than 40%; - Peak Oxygen Consumption less than 20 ml/Kg/min; - Stable Clinical Status. Exclusion Criteria: - Chronic Obstructive Pulmonary Disease; - Neuromuscular Diseases; - Orthopedic Diseases; - Neurologic Diseases; - Neoplastic Diseases; - Recent myocardial infarction or cardiac surgery (less than 6 months); - Unstable angina pectoris; - Atrial Fibrillation; - Pacemakers users; - Changing medication or hospital admission.

Additional Information

Official title Effects of Exercise Training on Mechanoreflex and Metaboreflex Control of Muscle Sympathetic Nerve Activity in Heart Failure Patients
Principal investigator Carlos E Negrão, PhD
Trial information was received from ClinicalTrials.gov and was last updated in September 2013.
Information provided to ClinicalTrials.gov by University of Sao Paulo General Hospital.