Acute Vascular Response To Meals Varying In Glycemic Index And Glycemic Load
This trial is active, not recruiting.
|Treatments||boiled pasta, boiled chickpeas with oil, instant mashed potatoes, instant mashed potatoes with egg whites|
|Sponsor||St. Michael's Hospital, Toronto|
|Start date||August 2010|
|End date||September 2011|
|Trial size||21 participants|
|Trial identifier||NCT01883700, 10-028|
This study examines the effects of carbohydrate type (high- or low-Glycemic Index (GI)) and amount (high- or low-Glycemic Load (GL)) have on blood glucose levels, blood pressure and arterial stiffness in healthy individuals. It will also determine whether subjective ratings such as test meal palatability and hunger are related to changes in blood glucose. The investigators hypothesize that: (1) High-GI meals, regardless of GL, will increase arterial stiffness; low-GI meals, regardless of GL, will have a neutral or lowering effect on arterial stiffness (augmentation index). (2) High-GI meals, regardless of GL, will have an elevating effect on both central and peripheral blood pressures. (3) The incremental area under the curve for blood glucose will show most significant differences between high-GI, high-GL and low-GI, low-GL meals at 30 and 90 min.
|Endpoint classification||efficacy study|
|Intervention model||crossover assignment|
To measure postprandial changes in augmentation index (AIx) to determine the acute effect of high- and low-GI and high- and low-GL meals on arterial stiffness.
time frame: 4 separate mornings, measurements taken at baseline and at 60, 120, 180 and 240 minutes
To determine the acute effect of high- and low-GI and high- and low- GL meals on central and peripheral blood pressure
time frame: 4 separate mornings, measurements taken at baseline, 60, 120, 180 and 240 minutes.
Male or female participants from 18 years up to 75 years old.
- age 18 - 75 years
- BMI 18 - 25 kg/m2
- brachial systolic blood pressure < 140 mmHg
- brachial diastolic blood pressure < 90 mmHg
- primary hypertension
- allergy or sensitivity to any foods to be used in the study
- gastrointestinal disorders
- chronic kidney disease
- liver disease
- estrogen-sensitive cancer
- heavy alcohol use
- sleep apnea
- bleeding disorders
- planned surgery (within time frame of study)
- Congestive Heart Failure
- coronary revascularization
- peripheral vascular disease and/or coronary/cerebrovascular events within the previous 6 months
- positive HIV diagnosis
- prescription of anti-depressants, anti-hypertensives, anti-coagulant medications, diuretics, sympathomimetics, herbal therapies, vitamin or K supplementation, medication affecting NO synthesis
- chronic use or prescription of NSAIDs
- women of childbearing potential must not be pregnant or breastfeeding
|Official title||Variability of Acute Response to Equicaloric Test Meals Varying in Glycemic Index and Glycemic Load on Postprandial Glycemia, Arterial Stiffness and Blood Pressure in Healthy Adults|
|Principal investigator||Alexandra Jenkins, PhD, RD|
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