Overview

This trial is active, not recruiting.

Conditions thoracic diseases, respiratory tract diseases, cancer of lung, cancer of the lung, lung cancer, lung diseases, obstructive, copd, pulmonary emphysema, neoplasms, lung, neoplasms, pulmonary, pulmonary cancer, pulmonary neoplasms, carcinoma, non-small-cell lung, carcinoma, small cell
Treatment skin biopsy
Sponsor Mayo Clinic
Start date September 2009
End date January 2017
Trial size 50 participants
Trial identifier NCT01860898, 09-005334

Summary

As part of the long-term goal of successfully implementing tissue regeneration strategies in an individualized manner for patients with thoracic diseases including, but not limited to: cystic fibrosis, pulmonary fibrosis and pulmonary hypertension, the investigators will assess the feasibility of collecting skin biopsies from patients undergoing surgery for thoracic disease, culturing skin fibroblasts from the biopsy, and reprogramming these skin fibroblasts into induced pluripotent cells.

United States No locations recruiting
Other Countries No locations recruiting

Study Design

Intervention model single group assignment
Masking open label
Primary purpose basic science
Arm
(Other)
skin biopsy
Biopsy samples will be taken as a 2mm x 2cm excision of a wedge of skin at the edge of the incision during your surgery at the Mayo Clinic Rochester. Such excisions are frequently done as part of routine skin closure for optimal skin cosmesis following the surgical procedure.

Primary Outcomes

Measure
Feasibility
time frame: 1 year

Eligibility Criteria

Male or female participants at least 18 years old.

Inclusion Criteria: - Undergoing Thoracic Surgery at the Mayo Clinic Rochester - Presence of a Thoracic Disease

Additional Information

Official title A Phase I Study of iPS Cell Generation From Patients With COPD
Principal investigator Dennis A Wigle, MD, PhD
Trial information was received from ClinicalTrials.gov and was last updated in June 2016.
Information provided to ClinicalTrials.gov by Mayo Clinic.