This trial is active, not recruiting.

Conditions glaucoma, open-angle, eye diseases
Sponsor Ohio State University
Start date May 2013
End date December 2014
Trial size 80 participants
Trial identifier NCT01857440, 2013H0073, 8KL2TR000112-05


This study is designed to investigate whether the pupil response to slowly flashing colored lights is significantly altered in patients with glaucoma, as compared to a control group of subjects without glaucoma.

United States No locations recruiting
Other countries No locations recruiting

Study Design

Observational model case control
Time perspective cross-sectional
This group will consist of patients with glaucoma who are under care at the Ohio State University Havener Eye Institute.
This group will consist of matched controls who are free of glaucoma and other complications, and who received a comprehensive eye examination at the Ohio State University College of Optometry.

Primary Outcomes

Pupil Response
time frame: Single Visit: One Day

Secondary Outcomes

Quality of Life Survey
time frame: Single Visit: One Day

Eligibility Criteria

Male or female participants at least 18 years old.

Inclusion Criteria: - 18+ years old - Diagnosed with glaucoma of known severity (cases only) - Have a refractive error between +4.00 and -8.00 sphere power, and no more than 3.00 diopters of astigmatism - Best corrected visual acuity of 20/40 or better in each eye - Have open anterior chamber angles Exclusion Criteria: - Diagnosis of glaucoma of a type other than Primary Open Angle (cases only) - History of having surgery or taking medications known to profoundly affect pupillary function or shape - Visual Field defect (controls only) - History of traumatic brain injury requiring hospitalization - Pregnancy - History of optic nerve disease other than glaucoma - History of retinopathy - History of unreactive pupils - Presence of significant cataract

Additional Information

Official title The Flashing Light-Induced Pupil Response (FLIPR) Glaucoma Study
Principal investigator Andrew Hartwick, OD, PhD
Description The pupils inside the eyes constrict in response to light stimulation. Different classes of cells within the human retina initiate this response. Recent research suggests that one of the ganglion cell types involved in this pupil response is affected by glaucoma. By measuring pupil responses to different colored lights, the function of this class of cells can be evaluated quickly, and without touching the eye. An advantage of pupil testing strategies is that they do not require subjective feedback from the subject about what they can see, as is required for standard visual field tests that are used in the clinic. The main aim of this study is to measure and compare the pupil constriction that occurs in response to flickering red and blue lights in patients with glaucoma versus matched control patients without glaucoma. In addition, the subjects will be asked questions about their quality of life and it will be determined whether issues related to quality of life correlate to alterations in the pupil responses.
Trial information was received from ClinicalTrials.gov and was last updated in October 2014.
Information provided to ClinicalTrials.gov by Ohio State University.