Overview

This trial is active, not recruiting.

Conditions coronary atherosclerosis, myocardial ischemia
Sponsor University of Bergen
Collaborator Haukeland University Hospital
Start date April 2013
End date December 2014
Trial size 132 participants
Trial identifier NCT01853527, 2012/2167b

Summary

The aim of the study is to assess presence of myocardial ischemia by contrast stress echocardiography in patients with symptomatic non-obstructive coronary artery disease (CAD) by CT-coronary angiography, and the clinical, vascular, biochemical and genetic markers of myocardial ischemia in such patients.

United States No locations recruiting
Other Countries No locations recruiting

Study Design

Observational model cohort
Time perspective prospective
Arm
Contrast stress echocardiography will be performed in patients with angina pectoris and non-obstructive CAD on CT-angiography to detect presence of myocardial ischemia

Primary Outcomes

Measure
Presence of myocardial ischemia by contrast stress echocardiography
time frame: 15 minutes, during contrast stress echocardopgraphy

Secondary Outcomes

Measure
Extent of myocardial ischemia by contrast stress echocardiography
time frame: 15 minutes, during contrast stress echocardiography

Eligibility Criteria

Male or female participants at least 30 years old.

Inclusion Criteria: - Age >30 years - Chest pain and or functional dyspnoea with a duration > 6 months - Non-obstructive coronary artery disease detected by CT coronary angiography Exclusion Criteria: - Significant coronary artery stenosis or normal coronary arteries by CT coronary angiography - Unstable coronary artery disease - Significant valvular heart disease - Mechanical valve prosthesis - Significant arrhythmia - Severly reduced pulmonary function (GOLD 3-4) - Known allergy to ultrasound contrast agents - Pregnancy - Inability to sign informed consent to participate - Other severe disease

Additional Information

Official title Myocardial Ischemia in Non-obstructive Coronary Artery Disease
Principal investigator Mai Tone Lønnebakken, MD, phd
Description Non-obstructive coronary artery disease (CAD) is particularly common in women and associated with reduced quality of life and increased cardiovascular morbidity and mortality. The project will recruit patients with angina pectoris and non-obstructive CAD by CT- coronary angiography for further imaging with contrast stress echocardiography for diagnosis of myocardial ischemia. Better characterization of patients with symptomatic non-obstructive CAD due to myocardial ischemia will be done by vascular assessment by tonometry, biochemical and genetic markers as well as quality of life questionnaire. This interdisciplinary project is expected to add new knowledge to the impact of multimodality cardiac imaging in improving diagnosis in patients with symptomatic non-obstructive CAD.
Trial information was received from ClinicalTrials.gov and was last updated in December 2014.
Information provided to ClinicalTrials.gov by University of Bergen.