Myocardial Ischemia in Non-obstructive Coronary Artery Disease
This trial is active, not recruiting.
|Conditions||coronary atherosclerosis, myocardial ischemia|
|Sponsor||University of Bergen|
|Collaborator||Haukeland University Hospital|
|Start date||April 2013|
|End date||December 2014|
|Trial size||132 participants|
|Trial identifier||NCT01853527, 2012/2167b|
The aim of the study is to assess presence of myocardial ischemia by contrast stress echocardiography in patients with symptomatic non-obstructive coronary artery disease (CAD) by CT-coronary angiography, and the clinical, vascular, biochemical and genetic markers of myocardial ischemia in such patients.
Contrast stress echocardiography will be performed in patients with angina pectoris and non-obstructive CAD on CT-angiography to detect presence of myocardial ischemia
Presence of myocardial ischemia by contrast stress echocardiography
time frame: 15 minutes, during contrast stress echocardopgraphy
Extent of myocardial ischemia by contrast stress echocardiography
time frame: 15 minutes, during contrast stress echocardiography
Male or female participants at least 30 years old.
Inclusion Criteria: - Age >30 years - Chest pain and or functional dyspnoea with a duration > 6 months - Non-obstructive coronary artery disease detected by CT coronary angiography Exclusion Criteria: - Significant coronary artery stenosis or normal coronary arteries by CT coronary angiography - Unstable coronary artery disease - Significant valvular heart disease - Mechanical valve prosthesis - Significant arrhythmia - Severly reduced pulmonary function (GOLD 3-4) - Known allergy to ultrasound contrast agents - Pregnancy - Inability to sign informed consent to participate - Other severe disease
|Official title||Myocardial Ischemia in Non-obstructive Coronary Artery Disease|
|Principal investigator||Mai Tone Lønnebakken, MD, phd|
|Description||Non-obstructive coronary artery disease (CAD) is particularly common in women and associated with reduced quality of life and increased cardiovascular morbidity and mortality. The project will recruit patients with angina pectoris and non-obstructive CAD by CT- coronary angiography for further imaging with contrast stress echocardiography for diagnosis of myocardial ischemia. Better characterization of patients with symptomatic non-obstructive CAD due to myocardial ischemia will be done by vascular assessment by tonometry, biochemical and genetic markers as well as quality of life questionnaire. This interdisciplinary project is expected to add new knowledge to the impact of multimodality cardiac imaging in improving diagnosis in patients with symptomatic non-obstructive CAD.|
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