Overview

This trial is active, not recruiting.

Conditions impaired glucose tolerance, diabetes
Sponsor St. Michael's Hospital, Toronto
Start date October 2012
End date May 2013
Trial size 770 participants
Trial identifier NCT01841229, MetaG

Summary

Ginseng (American ginseng, Asian ginseng, Korean ginseng etc) is expected to show positive hypoglycemic effects, including improvements in glycated blood proteins[HbA1c], fasting glucose, fasting insulin, and the homeostasis model assessment of insulin resistance [HOMA-IR]).

United States No locations recruiting
Other Countries No locations recruiting

Primary Outcomes

Measure
Glycated hemoglobin (HbA1c)
time frame: 1month

Secondary Outcomes

Measure
Fasting blood glucose
time frame: 1month
Fasting plasma insulin
time frame: 1 month
Homeostasis model assessment of insulin resistance (HOMA-IR)
time frame: 1 month

Eligibility Criteria

Male or female participants of any age.

Inclusion Criteria: - Dietary trials in humans - Randomized treatment allocation - 1 month - Suitable control - Viable endpoint data Exclusion Criteria: - Non-human studies - Non-randomized treatment allocation - <1 month - Lack of a suitable control - No viable endpoint data

Additional Information

Official title Effect of Ginseng on Glycemic Control: A Systematic Review and Meta-analysis of Controlled Trials to Provide Evidence-based Clinical Recommendations
Principal investigator Vladimir Vuksan, PhD
Description Ginseng has demonstrated to have significant hypoglycemic effect. Its major pharmacological component is considered to be ginsenosides. Several trials have been undertaken in diabetes some of which have demonstrated advantages in glycemic control in both diabetic as well as non diabetic individuals although clinical consistency of results is lacking.The lack of high quality data in this area to support diabetes recommendations represents an urgent call for stronger evidence. A systematic review and meta-analysis of controlled trials remains the "Gold Standard" of evidence for recommendations and clinical guidelines development. Therefore, investigators will conduct a systematic review and meta-analyses of controlled trials to assess the effect of ginseng on glycemic control.
Trial information was received from ClinicalTrials.gov and was last updated in May 2013.
Information provided to ClinicalTrials.gov by St. Michael's Hospital, Toronto.