BAR-trial: Bioavailability of Ethanol Following Bariatric Surgery
This trial is active, not recruiting.
|Treatments||gastric bypass, gastric sleeve|
|Sponsor||Norwegian University of Science and Technology|
|Collaborator||St. Olavs Hospital|
|Start date||September 2013|
|End date||December 2018|
|Trial size||30 participants|
|Trial identifier||NCT01840020, 2012/1206|
The first-pass metabolism (FPM) is a barrier to the toxicity of ethanol. Changes to the size and function of the stomach may alter FPM. Bariatric surgery, like the gastric bypass procedure, involves significant changes to the size and function of the stomach and leads to more rapid gastric emptying. Consequences will be faster absorption and higher peak concentration of ethanol after surgery than before. There are growing concerns that surgery for obesity in this way may cause alcohol abuse.
In this study the investigators compare changes in FPM of ethanol following two different bariatric surgical procedures.
|United States||No locations recruiting|
|Other Countries||No locations recruiting|
Change in bioavailability of ethanol
time frame: from baseline to 3 months, 1 year, and 3 years
Male or female participants from 18 years up to 60 years old.
Inclusion Criteria: - volunteers from Central Norway - morbid obese BMI > 40 kg/m2) - morbid obese BMI > 35 kg/m2 given a obesity related disease that qualifies for bariatric surgery Exclusion Criteria: - previous or current alcohol abuse - risk for alcohol harm as assessed by AUDIT - alcohol abstinence - liver disease except fatty liver, which occurs in more than 50% of those who seek bariatric surgery - previous colon resection - not/insufficiently able to informed consent - drugs that interact with alcohol dehydrogenase - drugs that slow down emptying of the stomach - pregnancy
|Official title||Changes in Bioavailability of Ethanol Following Bariatric Surgery|
|Principal investigator||Magnus Strommen, MSc|
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