Ectopic Lipid Deposition and Insulin Resistance in After Treatment of Acromegaly
This trial is active, not recruiting.
|Sponsor||Massachusetts General Hospital|
|Start date||April 2013|
|End date||January 2017|
|Trial size||46 participants|
|Trial identifier||NCT01819883, 2012P002517|
This study investigates fat distribution in people with acromegaly. The investigator is also investigating the change of fat distribution before and after treatment of acromegaly. The investigator will compare the results of people with acromegaly to the results of healthy volunteers.
All study subjects with acromegaly will be studied twice - once during the active stage of their disease (pre-treatment) and a second time: 3 months after treatment of acromegaly. Controls will be studied at one time point.
Change in liver fat and muscle fat over approximately three months
time frame: baseline and 3 month follow-up visit
All participants from 18 years up to 75 years old.
Inclusion Criteria: - Ages 18 - 75 yr (both groups) - Study subjects with active acromegaly - Healthy controls Exclusion Criteria: - Serum creatinine or alanine aminotransferase (ALT) > 2 times the upper limit of normal, metastatic cancer. - Controls will be receiving no medications and have no chronic diseases, including cancer, hypertension or diabetes mellitus. - Contraindications to MRI imaging (both groups) like those with certain metal implants, surgical clips or pacemakers. - Pregnant women
|Official title||Ectopic Lipid Deposition and Insulin Resistance in After Treatment of Acromegaly|
|Principal investigator||Karen Miller, MD|
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