Effect of Sacral Nerve Stimulation on Enteric Nervous System
This trial has been completed.
|Treatment||sacral nerve stimulation|
|Sponsor||University Hospital, Rouen|
|Collaborator||Nantes University Hospital|
|Start date||January 2013|
|End date||November 2016|
|Trial size||37 participants|
|Trial identifier||NCT01786304, 2012/091/HP|
Sacral nerve stimulation (SNS) is a new therapeutic option to treat fecal incontinence, although its mecanims of action remains poorly understood. The investigators hypothtized that SNS could act on enteric nervous system (ENS). To verify this hypothesis, the investigators will collect biopsy samples from patients implanted for SNS, and assess whether SNS induces changes in ENS.
Number of neurons producing vasoactive intestinal peptide (VIP)
time frame: 6 months
Number of cholinergic neurons
time frame: 6 months
Male or female participants from 18 years up to 75 years old.
Inclusion Criteria: - Fecal incotinence - refractory to medial treatment - Eligible to a treatment with sacral nerve stimulation Exclusion Criteria: - age < 18 yo - age < 75 yo - anal defect > 120° - bilateral interruption of the bulbo-cavernous reflex - patient not able to speack and understand the French Language - patient not affilated to the French healthcare system - pregnancy
|Official title||Effect of Sacral Nerve Stimulation on Enteric Nervous System|
|Principal investigator||Guillaume Gourcerol, MD, PhD|
|Description||Sacral nerve stimulation (SNS) is a new therapeutic option to treat fecal incontinence. Its efficacy yields 80% approximately, but its mecanims of action remains poorly understood. In particular, SNS does not restore anal squeezing contraction nor it increase anal tone. Recently, using a porcine model, it was shown that SNS changed colonic permeability, suggesting that SNS may activate the enteric nervous system (ENS). The investigators hypothtized therefore that SNS could act on enteric nervous system (ENS). To verify this hypothesis, the investigators will collect biopsy samples from patients before and after implantation for SNS. The investigators will assess whether SNS induces changes in ENS, and if this is correlated to SNS efficacy.|
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