Overview

This trial is active, not recruiting.

Condition obesity
Sponsor University Hospital, Antwerp
Collaborator Universiteit Antwerpen
Start date August 2009
End date March 2013
Trial size 203 participants
Trial identifier NCT01778868, ENDORUP

Summary

Hormonal disruption is the inappropriate alteration of the hormonal system by chemical substances that are present in our environment. Some chemical substances are capable of replicating, enhancing or reducing the production, release, transport or action of natural hormones. Therefore, they are called hormonal or endocrine disrupters. Some 'classic' endocrine disrupters such as pesticides and dioxins are considered responsible for infertility, cancer and thyroid problems. Recently, a number of additional chemical substances were stipulated to have endocrine disrupting capabilities. The industrial production of these substances in large quantities has led to an accumulation in our environment and thus possible negative consequences on human health.

The aim of this study is to investigate the rol of these chemical substances in the occurence of overweight and obesity.

United States No locations recruiting
Other Countries No locations recruiting

Study Design

Observational model cohort
Time perspective cross-sectional
Arm

Primary Outcomes

Measure
Serum levels of polychlorinated biphenyls
time frame: at the moment of entering a weight loss program
Serum levels of hydroxylated metabolites of polychlorinated biphenyls
time frame: at the moment of entering a weight loss program
serum levels of organochlorine pesticides
time frame: at the moment of entering a weight loss program
serum levels of polybrominated diphenyl ethers
time frame: at the moment of entering a weight loss program
Urinary levels of pollutants
time frame: at the moment of entering a weight loss program
Change in serum levels of polychlorinated biphenyls compared to the levels at the start of the weight loss program
time frame: after 3, 6 and 12 months of weight loss
change in serum levels of hydroxylated metabolites of polychlorinated biphenyls compared to the level at the start of the weight loss program
time frame: after 3,6 and 12 months of weigth loss
Change in serum levels of organochlorine pesticides compared to the level at the start of the weight loss program
time frame: after 3,6 and 12 months of weight loss
Change in serum levels of polybrominated diphenyl ethers compared to the level at the start of the weight loss program
time frame: After 3,6 and 12 months of weight loss
change in urine levels of pollutants compared to the level at the start of the weight loss program
time frame: after 3,6 and 12 months of weight loss

Eligibility Criteria

Male or female participants at least 18 years old.

Inclusion Criteria: - adult - Overweight (BMI > 25 kg/m²) or obesity (BMI > 30 kg/²) Exclusion Criteria: - Type 1 diabetes mellitus - psychiatric illness

Additional Information

Official title Endocrine Disrupting Environmental Chemicals: From Accumulation to Their Role in the Global "Neuro-endocrine" Epidemic of Obesity and Its Metabolic Consequences
Principal investigator Philippe Jorens, MD, PhD
Trial information was received from ClinicalTrials.gov and was last updated in January 2013.
Information provided to ClinicalTrials.gov by University Hospital, Antwerp.