Overview

This trial is active, not recruiting.

Conditions multiple sclerosis, respiratory; disorder, functional, impaired, difficulty walking
Treatment breathing exercises
Sponsor University Hospital Orebro
Collaborator Örebro County Council
Start date September 2012
End date December 2014
Trial size 50 participants
Trial identifier NCT01774201, OLL-260361

Summary

Multiple sclerosis (MS) is a chronic progressive neurological disease. Respiratory dysfunction due to weakness in the respiratory musculature has been described in MS. This leads to increased morbidity and mortality in late stages of the disease. It is possible that respiratory dysfunction influence physical fitness in earlier stages as well. Walking disability and fatigue causes significant impact on health in patients with MS, even in earlier stages.

The hypothesis is that there is a relationship between respiratory function, walking capacity and fatigue and that daily deep breathing exercise during two months will improve respiratory function, walking capacity and fatigue.

United States No locations recruiting
Other Countries No locations recruiting

Study Design

Allocation randomized
Endpoint classification efficacy study
Intervention model parallel assignment
Masking single blind (investigator)
Primary purpose treatment
Arm
(Experimental)
Daily deep breathing exercises during two month
breathing exercises
(No Intervention)
Control group

Primary Outcomes

Measure
Respiratory muscle strength
time frame: Two months

Eligibility Criteria

Male or female participants of any age.

Inclusion Criteria: - Inhabitant in Örebro county, Sweden, that are diagnosed with MS according to the revised McDonald criteria and registered in the Swedish MS-registry with EDSS (Expanded disability status scale) score in the interval ≥ 3.0 - ≤ 7.0. - Participants must understand verbal and written information and must be relapse free ≥ 3 months prior to inclusion. Exclusion Criteria: - Patients with diseases that may have influence on walking ability and respiratory function (other than MS). Such conditions include heart and lung diseases, orthopedic disorders, patients recently subjected to surgery, and non-MS related neurological dysfunction.

Additional Information

Official title Respiratory Function and Walking Capacity in Multiple Sclerosis
Principal investigator Elisabeth Westerdahl, Phd
Trial information was received from ClinicalTrials.gov and was last updated in January 2013.
Information provided to ClinicalTrials.gov by University Hospital Orebro.