This trial has been completed.

Conditions multiple sclerosis, respiratory; disorder, functional, impaired, difficulty walking
Treatment breathing exercises
Sponsor Region Örebro County
Collaborator Örebro County Council
Start date September 2012
End date December 2014
Trial size 50 participants
Trial identifier NCT01774201, OLL-260361


Multiple sclerosis (MS) is a chronic progressive neurological disease. Respiratory dysfunction due to weakness in the respiratory musculature has been described in MS. This leads to increased morbidity and mortality in late stages of the disease. It is possible that respiratory dysfunction influence physical fitness in earlier stages as well. Walking disability and fatigue causes significant impact on health in patients with MS, even in earlier stages.

The hypothesis is that there is a relationship between respiratory function, walking capacity and fatigue and that daily deep breathing exercise during two months will improve respiratory function, walking capacity and fatigue.

United States No locations recruiting
Other countries No locations recruiting

Study Design

Allocation randomized
Endpoint classification efficacy study
Intervention model parallel assignment
Masking single blind (investigator)
Primary purpose treatment
Daily deep breathing exercises during two month
breathing exercises
Breathing exercises with positive expiratory pressure.
(No Intervention)
Control group

Primary Outcomes

Respiratory muscle strength
time frame: Two months

Eligibility Criteria

All participants of any age.

Inclusion Criteria: - Inhabitant in Orebro county, Sweden, that are diagnosed with MS according to the revised McDonald criteria and registered in the Swedish MS-registry with EDSS (Expanded disability status scale) score in the interval ≥ 3.0 - ≤ 7.0. - Participants must understand verbal and written information and must be relapse free ≥ 3 months prior to inclusion. Exclusion Criteria: - Patients with diseases that may have influence on walking ability and respiratory function (other than MS). Such conditions include heart and lung diseases, orthopedic disorders, patients recently subjected to surgery, and non-MS related neurological dysfunction.

Additional Information

Official title Respiratory Function and Walking Capacity in Multiple Sclerosis
Principal investigator Elisabeth Westerdahl, Phd
Description Presented above.
Trial information was received from ClinicalTrials.gov and was last updated in January 2017.
Information provided to ClinicalTrials.gov by Region Örebro County.