Ischaemia-réperfusion During the Coronary Surgery With Beating Heart
This trial is active, not recruiting.
|Treatments||placebo, diltiazem, acetylcystein, diltiazem and acetylcystein|
|Sponsor||University Hospital, Strasbourg, France|
|Start date||June 2002|
|End date||February 2008|
|Trial size||120 participants|
|Trial identifier||NCT01771978, 2276|
Less oxidative stress occurs during off-pump than on-pump coronary artery bypass graft (CABG) surgery but warm ischaemia-reperfusion injury may occur following transient coronary artery clamping. The aim of this study was to compare the preventive effects of diltiazem and N-acetylcysteine (NAC), alone or in combination, on biomarkers of myocardial damage and oxidative stress during off-pump CABG surgery.
|Endpoint classification||efficacy study|
|Intervention model||parallel assignment|
Reduce the percentage 40% of patients operated on a beating heart to 10% as a result of treatment with diltiazem and N-acetylcysteine
time frame: during ischaemia-reperfusion
Male or female participants from 60 years up to 80 years old.
Inclusion Criteria: - Age included between 60 and 80 years Exclusion Criteria: - Age < 60 or > 80 years - Pregnancy - The allergy in used medicines (N-acétylcystéine, Diltiazem) - Presence of a pathology valvulaire associated - Urgency - Unstable angor - Bypass as a matter of urgency - Recours peropératoire to a CEC - FE < 0,40 - BAV of the 2nd and 3rd not sailed degree - fibrillation or flutter little finger.
|Official title||Effects of Diltiazem and/or N-Acétylcystéine Versus Placebo on hémodynamiques and Biological Repercussions of the Ischaemia-réperfusion During the Coronary Surgery With Beating Heart|
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