This trial is active, not recruiting.

Conditions obesity, endothelial dysfunction, insulin resistance
Sponsor Monica Montagnani
Start date April 2012
End date March 2013
Trial size 60 participants
Trial identifier NCT01750333, OBETAD-01


The aim of this study is to explore whether and how high circulating levels of endothelin-1 (ET-1) in obese and overweight children may contribute to impair adiponectin (Ad) production, release and vascular activity

United States No locations recruiting
Other Countries No locations recruiting

Study Design

Observational model cohort
Time perspective retrospective

Primary Outcomes

Correlation between serum levels of ET-1 and Ad in lean, overweight and obese children
time frame: 12 months

Eligibility Criteria

Male or female participants from 5 years up to 13 years old.

Inclusion Criteria: - Children will be enrolled into lean, overweight or obese groups based on Body mass index (BMI) calculated according to standard methods. International standards for sex-and age-specific BMI centiles for subjects aged 2-18 years will be used. The 95th centile of BMI reference is the cut off point for childhood obesity. Overweight and obese children are defined as those with a BMI higher than the centile curves. Exclusion Criteria: - presence of renal, liver and/or cardiovascular diseases; - hypertension; - metabolic and/or endocrine disorders; - genetic syndromes; - histories of chronic allergies, acute infectious or inflammatory diseases during the last 3 months preceding the study

Additional Information

Official title Observational Retrospective Study on Correlation Between ET-1 and Ad in Obese Children
Principal investigator Monica Montagnani, MD, PhD
Trial information was received from ClinicalTrials.gov and was last updated in December 2012.
Information provided to ClinicalTrials.gov by Montagnani, Monica, M.D., Ph.D..