Mommy-Baby Treatment for Perinatal Depression
This trial is active, not recruiting.
|Conditions||depressive disorder, major, postpartum depression|
|Treatments||dyadic interpersonal psychotherapy, enhanced treatment as usual|
|Sponsor||Washington University School of Medicine|
|Collaborator||National Institute of Mental Health (NIMH)|
|Start date||November 2012|
|End date||October 2016|
|Trial size||42 participants|
|Trial identifier||NCT01744041, 201203136, K23MH090245|
Perinatal depression is a major public health problem, affecting 15% of women during pregnancy through the postpartum period, with adverse consequences for the mother, the fetus, the infant, and the family. Despite increasing evidence of the importance of this critical risk interval, little research has investigated the effects of depression treatment during pregnancy on infant outcomes. The purpose of this study is to test the feasibility, acceptability, and effectiveness of a new intervention, Interpersonal psychotherapy for the mother-infant dyad (IPT-Dyad). This intervention begins during pregnancy and continues with the mother and infant until one year postpartum. The investigators hypothesize that IPT-Dyad will be better than treatment as usual in reducing depressive symptoms, improving psychosocial functioning,increasing parenting self-efficacy, improving infant emotional development, and enhancing mother-infant relationship quality.
|Intervention model||parallel assignment|
Change in Edinburgh Depression Scale from Baseline
time frame: Change from baseline at End of pregnancy (between 37-39 weeks gestation); change from baseline at 3 months postpartum; change from baseline at 6 months postpartum; change from baseline at 9 months postpartum; change from baseline at 12 months postpartum
Female participants at least 18 years old.
Inclusion Criteria: - Pregnant women - 18 years and older - between 12 and 30 weeks gestation - Score greater than or equal to 13 on Edinburgh Depression Scale - Structured Clinical Interview (SCID-IV) diagnosis of Major Depressive Disorder, dysthymia, or Depressive Disorder, Not otherwise Specified - English Speaking Exclusion Criteria: - Substance abuse or dependence in past 3 months - Active suicidal or homicidal ideation - Bipolar disorder, psychotic disorder - unstable medical condition or other medical/obstetrical complication - Evidence of severe intimate partner violence - Ongoing psychosocial or pharmacotherapy for depression
|Official title||Perinatal Depression: Dyadic-IPT to Improve Health of Mother and Baby|
|Principal investigator||Shannon Lenze, Ph.D.|
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