This trial is active, not recruiting.

Condition parents of healthy newborns
Treatments genetics education at baseline, hypothetical genomic scenarios at follow-up
Sponsor Brigham and Women's Hospital
Start date June 2012
End date September 2014
Trial size 1101 participants
Trial identifier NCT01736501, 2012-P-001197


A 10 minute baseline survey will be administered to parents of healthy newborn infants while in the hospital after delivery at Brigham and Women's Hospital, to be followed by a 25 minute survey 3-24 months later. We will measure parents' attitudes and preferences related to genome screening of newborns. The specific aims of this study are:

1. To investigate whether parents' opinions regarding genome screening of newborns change between the first 48 hours post-partum and 3-24 months post-partum.

a. We hypothesize that there will not be significant differences between interest in genome screening results in the 48 hours post-partum compared to 3-24 months post-partum.

2. To determine whether seeing hypothetical genome screening results affects parents' decisions regarding whether they would want genome screening for their newborn.

1. We expect many parents to state initially (in the 48 hours post-partum) that they would elect to have genome screening for their newborn if it were available. In the follow-up survey, half of study participants will receive hypothetical scenarios in which they will need to struggle with the probabilistic and ambiguous nature of the information that could be derived from genome sequencing. We will examine whether this alters their preferences. We will also explore whether parents who receive hypothetical genome screening results scenarios are more likely to alter their preferences than parents who do not receive hypothetical scenarios.

United States No locations recruiting
Other countries No locations recruiting

Study Design

Allocation randomized
Intervention model factorial assignment
Masking open label
Primary purpose health services research
(No Intervention)
Baseline survey- demographics only
Genetics education, baseline interest in genome screening - 1
genetics education at baseline
Baseline survey- demographics only
hypothetical genomic scenarios at follow-up
Genetics education, baseline interest in genome screening - 2
genetics education at baseline
hypothetical genomic scenarios at follow-up

Primary Outcomes

Interest in genome screening for newborn if this service were available through a research study
time frame: Change between baseline and 3-24 month follow-up

Secondary Outcomes

Rate of refusal of newborn screening
time frame: baseline

Eligibility Criteria

Male or female participants of any age.

Inclusion Criteria: - Parent of a healthy newborn in the BWH Department of Obstetrics - English-speaking Exclusion Criteria: - Impaired decision-making capacity - Newborn with life-threatening health concerns in the 48 hours post-partum

Additional Information

Official title Surveying Parents About Genome Screening of Newborns
Principal investigator Robert C. Green, MD, MPH
Trial information was received from ClinicalTrials.gov and was last updated in July 2015.
Information provided to ClinicalTrials.gov by Brigham and Women's Hospital.