Sleep Deprivation's Regulation of Immune System Function and Behavior
This trial is active, not recruiting.
|Conditions||sleep deprivation, sleep|
|Treatments||neuroeconomics task, portion size task, blood sample|
|Start date||February 2012|
|End date||March 2013|
|Trial size||18 participants|
|Trial identifier||NCT01730742, 192837465|
The study proposes to investigate whether sleep deprivation will affect a variety of measures, including hormones, immune system functioning, and behaviors related to food intake and hunger. It is predicted that sleep deprivation will affect circulating neutrophil activity, and do so via affects on DNA methylation. It is also predicted that sleep deprivation will up-regulate ghrelin, and down-regulate circulating oxytocin. Finally, it is predicted that sleep deprivation will increase participants' tendencies to pick larger portions of food, and also increase their tendency to purchase foods that are more caloric in a mock supermarket scenario.
|Intervention model||crossover assignment|
|Primary purpose||basic science|
Neutrophil phagocytotic function production
time frame: Change in 4 neutrophil phagocytotic function from baseline to 36hours later (after the nighttime intervention)
Portion Size Task
time frame: Change in selected portion size from baseline to 1 hr after consuming a caloric preload
time frame: Change in purchasing behaviour 1 hr after consuming a caloric preload
Circulating hormone levels
time frame: Change in circulating hormone levels from baseline (ie. 1930 - before sleep intervention) to 12hr later (0730 after the nighttime intervention)
Male participants of any age.
Inclusion Criteria: - Male - Age 18-35y - Healthy (self-reported) and not on medication - Non-smoking - Normal sleep-wake rhythm (i.e. 7-8 h per night, self-reported) Exclusion Criteria: - Major illness - Taking any serious medications - Any sleep conditions (e.g. irregular bedtimes, sleep complaints) - Any dietary issues with the food items provided - A history of endocrine or psychiatric disorders
|Official title||The Role of Sleep Deprivation in the Regulation of Immune System, Neuroendocrine Responses, and Behavioral Measures.|
|Principal investigator||Christian Benedict, PhD|
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