fMRI of Stress in Obesity
This trial is active, not recruiting.
|Start date||May 2008|
|End date||May 2015|
|Trial size||60 participants|
|Trial identifier||NCT01719484, 0805003899|
To examine the influence of obesity on brain activation during food cue, stress, and neutral relaxing conditions
|Observational model||case control|
Subjects deemed to be medically healthy
Subjects deemed to be medically obese
No outcome measures for this study, this is an imaging study only
time frame: Upon study completion
Male or female participants from 18 years up to 50 years old.
Inclusion Criteria: 1. Between ages 18-50 years old. 2. Able to read and write. 3. negative urine toxicology screens during intake appointments indicating no history of current or past dependence on alcohol or illicit drug use. 4. WOMEN: have a regular menstrual cycle. 5. BMI: 30 < BMI < 35 for obese subjects (upper limit of 35 selected given our experience with heavier individuals fitting comfortably in the fMRI scanner) and 18.5 < BMI <25 for normal weight subjects (Institute, 2006) Exclusion Criteria: 1. any major neurological illness or injury and any current or prior clinically significant mental health (including PTSD) or substance use disorder (with exception of nicotine dependence) as determined by SCID interview; 2. Regular use of any psychoactive drugs including anxiolytics and antidepressants. 3. Any significant current medical condition such as neurological, cardiovascular, endocrine, renal, liver, thyroid pathology; subjects on medications for any medical condition will be excluded. 4. Any subjects with foreign ferromagnetic metal objects in their body or other MR contraindications will be excluded including subjects who work as welders. 5. Women on oral contraceptives, peri- and post-menopausal women, and pregnant or lactating women (as alterations in stress response are associated with these states).
|Official title||Functional Magnetic Resonance Imaging of Stress in Obesity|
|Principal investigator||Marc N Potenza, MD, PhD|
|Description||Subjects will participate in an fMRI session to examine changes in frontal and limbic brain regions with food cues, stress and neutral/relaxing imagery|
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