Reduction of Obesity-Associated Intestinal Inflammation by Low-Fat Dairy Yogurt
This trial is active, not recruiting.
|Conditions||intestinal barrier function, chronic inflammation|
|Treatments||low fat dairy yogurt, soy pudding|
|Sponsor||University of Wisconsin, Madison|
|Collaborator||Dairy Research Institute|
|Start date||September 2012|
|End date||December 2016|
|Trial size||132 participants|
|Trial identifier||NCT01686204, 2014-0669|
The main objective of this work is to conduct a clinical trial in obese and non-obese individuals testing the ability of low-fat dairy yogurt to improve gastrointestinal health and reduce chronic inflammation. Our central hypothesis is that short and long-term consumption of low-fat dairy yogurt will reduce inflammation to a greater extent in obese individuals by improving intestinal barrier function.
|Intervention model||parallel assignment|
|Primary purpose||basic science|
Plasma soluble cluster of differentiation 14 (sCD14)
time frame: Change from baseline at 3, 6, and 9 weeks
Plasma Interleukin (IL)-6
time frame: Baseline, 3, 6, 9 weeks
Female participants from 21 years up to 55 years old.
Inclusion Criteria: - premenopausal women - BMI from 18.5-27 and 30-40 kg/m2 - resting blood pressure <140/90 mmHg - not taking medication to control hypertension - stable body weight for the previous 2 months - willing to maintain a normal exercise level and avoid exercise 24 h prior to blood sampling - willing to avoid yogurt and probiotic-containing foods or consume 2 servings of yogurt for the duration of the study Exclusion Criteria: - previous diagnoses of cardiovascular disease (CVD), diabetes, or arthritis (except for osteo-arthritis) - currently being treated for cancer (i.e., chemotherapy, radiation therapy) - prescribed estrogen replacement therapy - practicing weight-loss, vegetarian, kosher, or vegan diets - currently taking dietary supplements - exceed alcohol consumption more than moderate drinking (1 drink/day or a total of 7/week) - actively using antibiotics - taking anti-inflammatory drugs - have allergies to soy, egg or milk - perimenopausal or menopausal symptoms
|Official title||Reduction of Obesity-Associated Intestinal Inflammation by Low-Fat Dairy Yogurt|
|Principal investigator||Bradley W Bolling, PhD|
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