Overview

This trial is active, not recruiting.

Conditions mental disorders, addictive behaviors, cannabis use disorder
Treatments acra, cbt
Sponsor University of Connecticut Health Center
Collaborator National Institute on Drug Abuse (NIDA)
Start date September 2011
End date July 2016
Trial size 172 participants
Trial identifier NCT01656707, PA08-263, R01DA030454

Summary

The purpose of this study is to examine an Adaptive Treatment approach in order to improve outcomes of youth with Cannabis Use Disorders who are poor responders to treatment.

United States No locations recruiting
Other Countries No locations recruiting

Study Design

Allocation randomized
Endpoint classification efficacy study
Intervention model parallel assignment
Masking open label
Primary purpose treatment
Arm
(Experimental)
Ten weekly 60-minute sessions of Adolescent Community Reinforcement Approach (ACRA) will be provided as an Adaptive treatment condition.
acra Adolescent Community Reinforcement Approach
Ten weekly,60-minute therapy sessions including six individual, two parent/guardian and two joint (individual and parent/guardian).
(Experimental)
Ten weekly, 60-minute sessions of augmented individualized Cognitive Behavioral Therapy (CBT)will be provided as an Adaptive Treatment condition
cbt Cogntive Behavioral Therapy
10 weekly, 60-minute sessions of augmented individualized CBT

Primary Outcomes

Measure
1.) To evaluate the efficacy of AT for youth who have been defined as poor responders to an evidence-based practice intervention such as the initial MET/CBT-7.
time frame: one year

Secondary Outcomes

Measure
To assess outcomes as a function of mediator variables such as self-efficacy, coping skills, readiness to change, and environmental support (i.e., family and peer), within each of the AT interventions.
time frame: one year

Eligibility Criteria

Male or female participants from 13 years up to 18 years old.

Inclusion Criteria: - 13-18 years of age at the time of intake assessment - Current diagnosis of DSM-IV Cannabis Abuse or Dependence - Able to read and comprehend English at a 5th grade level - Residence within 45 minutes drive from the UCHC Farmington treatment site - Participant and a parent/legal guardian responsible for providing collateral information agree to sign an IRB approved consent form - Participant and a parent/legal guardian responsible for providing collateral information agree to provide locator information - The family is not planning to move from the area during the next six months Exclusion Criteria: - Meet criteria for dependence of any other substance of abuse other than nicotine or alcohol - Report suicidal ideation with a plan, suicidal behavior, a plan to hurt oneself or other, or a history of self-injurious behavior all occurring in the last 30 days - Meet a lifetime diagnosis of schizophrenia - Has any current health (i.e. medical, psychiatric) condition that will compromise the participant's ability to regularly attend treatment - Demonstrate an inability or unwillingness to provide locator information

Additional Information

Official title Adaptive Treatment for Adolescent Cannabis Use Disorders
Principal investigator Yifrah Kaminer, MD, MBA
Description The study will address the current contrasts in youth response to treatment, the problem of poor response to treatment and the prevention of relapse. Results from the study may support Adaptive Treatment as an efficacious approach for youth with Cannabis Use Disorder who are poor responders to treatment. Poor responders fall into two categories, those who failed to achieve a negative drug urinalysis during the last session of the initial MET/CBT-7 treatment they attended, and those who either dropped out or were administratively discharged at any time during the initial MET/CBT-7 treatment.
Trial information was received from ClinicalTrials.gov and was last updated in May 2016.
Information provided to ClinicalTrials.gov by University of Connecticut Health Center.