Overview

This trial is active, not recruiting.

Condition low bone density
Treatments teriparatide, alendronate, calcium and vitamin d
Sponsor Johns Hopkins University
Start date August 2012
End date August 2017
Trial size 46 participants
Trial identifier NCT01656629, NA_00050448

Summary

Osteoporosis is an important health problem in the rapidly-aging demographic. Fragility fractures are devastating consequences of osteoporosis. The most common treatment approach in osteoporosis is inhibition of bone resorption with drugs like alendronate (ALN). Parathyroid hormone (PTH) stimulates bone formation and is the only anabolic drug available. Dual therapy with ALN and PTH is not as effective as single-drug therapy in preventing fracture. Bone progenitor cells (MSCs) are recruited to sites of bone remodeling when a growth factor called Transforming Growth Factor Beta (TGF-β1) is released from bone. Different osteoporosis medicines may have differing effects on this process. The effects of ALN versus PTH on bone progenitor recruitment in humans are unknown. This is a randomized, clinical trial of ALN, PTH, and calcium and vitamin D in post-menopausal women with low bone mass. Women will be treated for 3 months with ALN or PTH or calcium and vitamin D. Data collected will include bone biopsies for histomorphometry and micro computed tomography (µCT), bone marrow aspirates for molecular studies, peripheral blood to detect circulating bone progenitor cells and dual X-ray absorptiometry. The investigators hypothesize that in humans, PTH will 1) increase bone progenitor number, 2) enhance recruitment of bone progenitor cells to bone resorption sites, and 3) increase bone progenitor number in peripheral circulation. Furthermore, the investigators hypothesize that ALN treatment will have the opposite effect. Understanding the differences in bone progenitor cell activity and recruitment during osteoporosis therapy will provide a mechanistic rationale for effective use of PTH and anti-resorptive drugs in osteoporosis treatment.

United States No locations recruiting
Other Countries No locations recruiting

Study Design

Allocation randomized
Intervention model single group assignment
Masking open label
Arm
(Active Comparator)
teriparatide 20 mcg sq for 3 months
teriparatide
20 mcg subq daily for 3 months
(Active Comparator)
70 mg po weekly for 3 months
alendronate
70 mg weekly for 3 months
(Active Comparator)
calcium 630 mg vitamin D 500 units daily for 3 months
calcium and vitamin d

Primary Outcomes

Measure
The percent change in circulating osteoprogenitor cells as assessed by flow cytometry in the blood before and after treatment with PTH or ALN.
time frame: up to 3 months

Secondary Outcomes

Measure
Difference in bone formation as assessed by bone histomorphometry on bone biopsy between treatment groups
time frame: 3 months
Difference in osteogenic potential of bone marrow as measure by colony forming unit osteoblast (CFU-Ob) assays between treatment groups
time frame: 3 months

Eligibility Criteria

Female participants from 50 years up to 80 years old.

Inclusion Criteria: - Post-menopausal women aged 50-80 years - T score < -2.5 at lumbar spine, total hip or femoral neck on dual x-ray absorptiometry (DXA) OR T score < -1.5 with a personal or family history of fracture Exclusion Criteria: - Previous use of bisphosphonates or PTH; current estrogen therapy; any other osteoporosis therapy in the past 6 months - Metabolic bone disease other than osteoporosis - BMI<18 - Weight > 325 lbs - Current smoking or current alcohol use that exceeds 3 units of alcohol daily - Use of medications known to affect bone metabolism - Renal disease, history of kidney stones or hypercalciuria - Hypo- or hyperparathyroidism; hypo- or hypercalcemia - Serum vitamin D level < 20 ng/dL - Refusal to adjust their dietary calcium to <750mg (i.e. two servings per day of calcium rich food) - History of bone marrow or organ transplant - History of malignancy or radiation to the bone - History of esophageal stricture, dysmotility or severe reflux disease - Gastrointestinal malabsorption - Use of digoxin - Need for chronic anticoagulation therapy such as Coumadin, heparin or low molecular weight heparin or inability to discontinue anti-platelet medication - Bleeding diathesis; hemoglobin ≤ 12.5 g/dL (American Red Cross cut-off to donate blood) - International normalized ratio (INR) pro time > 1.1 or activated partial thromboplastin time (APT) T ratio > 1.2 - Platelets < 150K/cu mm - Cellulitis at site of iliac crest - History of allergy to medications used in bone biopsy (demeclocycline, lidocaine) - Inability to understand and provide informed consent.

Trial information was received from ClinicalTrials.gov and was last updated in August 2016.
Information provided to ClinicalTrials.gov by Johns Hopkins University.