Intensity of Exercise and Glucose Metabolism
This trial is active, not recruiting.
|Sponsor||University of Oulu|
|Collaborator||Finnish Diabetes Association|
|Start date||January 2010|
|End date||June 2010|
|Trial size||80 participants|
|Trial identifier||NCT01649219, 64/2009|
Our aim is to investigate the effects of a 12-week structured aerobic exercise on fasting and 2 h glucose, insulin and lipid concentrations in sedentary overweight subjects in whom impaired fasting glucose and/or impaired glucose tolerance was observed for the first time.
|Endpoint classification||safety/efficacy study|
|Intervention model||parallel assignment|
3-month supervised exercise intervention 3 times per week; 60min per time.
Standard couselling at baseline
Glucose and lipid metabolism
time frame: 3-month intervention
Changes in muscle metabolism
time frame: 3-months intervention
Male or female participants from 30 years up to 70 years old.
Inclusion Criteria: - prediabetes determined by 2 hr oGTT Exclusion Criteria: - any functional limitation or chronic disease that might have limited the physical exercise and testing - vigorous physical activity/exercise as revealed by questionnaire and physician exam
|Principal investigator||Karl-Heinz Herzig, MD,PhD|
|Description||Study type: Interventional Study design: Randomized Endpoint classification: Changes in fasting and 2 h glucose, insulin and lipid concentrations Intervention model: Parallel assignment Masking: Open label Primary purpose: Prevention and dose response assessment of exercise on glucose and lipid metabolism Condition: Prediabetes Intervention: Supervised exercise - The training sessions of the intervention group are carried out indoors 3 times a week for 3 months and supervised by an exercise instructor and physician. Each session last for 60 min and include a 5-min warm-up and stretching, a 20-min walking at speeds 2-4 km/h depending of the participant's physical condition, a 5-min stretching and balance training, a 20-min walking, and a 10-min stretching and balance training. After 1.5 months the 5-min stretching and balance training between the two 20-min walkings is excluded, and the walking time become 45 min. No intervention: control group; couseling at baseline. Participants of the control group are advised to continue their usual physical and dietary habits. Experimental: 1 -supervised exercise intervention. No intervention: 2 - standard counseling at baseline.|
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