Role of Adipokines in Glucose Regulation During Pregnancy and in Fetal Development
This trial is active, not recruiting.
|Conditions||gestational diabetes, insulin resistance|
|Sponsor||Université de Sherbrooke|
|Collaborator||Fonds de la Recherche en Santé du Québec|
|Start date||January 2010|
|End date||January 2019|
|Trial size||1086 participants|
|Trial identifier||NCT01623934, DG2A1|
This study includes 2 phases. During phase 1, pregnant women are followed over the course of pregnancy. The phase 2 is a follow-up of the mother-child dyad at 3 and 5 year after delivery.
The purpose of this phase 1 is to :
- assess the contribution and interactions of adipokines in the development of insulin resistance during pregnancy and gestational diabetes;
- assess levels of maternal adipokines as determinants of development and fetal growth;
- determine the genetic variations that influence levels of adipokines and glucose regulation during pregnancy and in newborns.
The purpose of this phase 2 is to:
- identify DNA methylation variations at birth that are predictive of childhood overweight/obesity.
- identify maternal characteristics associated with DNA methylation variations predictive of childhood overweight/obesity.
- establish whether the loci predictive of childhood overweight/obesity at birth are still differentially methylated at 5 years of age (samples collected at 5 years of age).
- identify DNA methylation variations at birth that are predictive of childhood neurodevelopment problems at 3 and 5 years of age.
Diagnosis of gestational diabetes mellitus
time frame: 24-28 weeks of gestation
Female participants at least 18 years old.
Inclusion Criteria: - age ≥ 18 yrs - gestational age between 6 and 13 weeks from last menstrual period - no recognized diabetes or drugs interfering with glucose metabolism - alcohol < 2 drinks/day - not involved in regular high intensity physical activity - otherwise good health status Exclusion Criteria: - twin pregnancy
|Official title||Role of Adipokines in Glucose Regulation During Pregnancy and in Fetal Development|
|Principal investigator||Marie-France Hivert, MD, MSc|
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